Lege Artis Medicinae - 2008;18(11)

Lege Artis Medicinae

NOVEMBER 10, 2008

[DISEASES OF THE EXOCRINE PANCREAS AND DIABETES MELLITUS]

CZAKÓ László

[Exocrine and endocrine pancreas constitutes close anatomical and functional links accordingly, any disease affecting one of these sectors will inevitably affect the other. Acute and chronic pancreatitis, pancreatic surgery, cystic fibrosis and pancreatic cancer are those pancreatic conditions that might cause diabetes mellitus. The development of diabetes greatly influences the prognosis and quality of life of patients with exocrine pancreatic diseases. The lack of glucagon and the impaired... tovább »

Lege Artis Medicinae

NOVEMBER 10, 2008

[CRITICAL SITUATIONS IN SYSTEMIC AUTOIMMUNE DISEASES]

KISS Emese, SOLTÉSZ Pál, RÉTI Katalin, POÓR Gyula, SZEGEDI Gyula

[Systemic autoimmune diseases characteristically show multiple organ involvements. Hence, Clinical manifestations and the outcome are quite variable. The survival has continuously been improving due to more sophisticated diagnostic tools and therapeutic possibilities. Despite the technical development, complications and organ manifestations may lead to emergency or often provoke permanent functional or morphologic deterioration of the affected organs. Critical situations can be directly... tovább »

Lege Artis Medicinae

NOVEMBER 10, 2008

[INCRETIN MIMETICS AND INCRETIN ENHANCERS: NEW THERAPEUTIC TOOLS IN THE TREATMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS]

JERMENDY György

[Incretins are hormone-like peptides secreted by specific cells of the small intestine mucosa. Their two main representatives are the glucagon-likepeptide- 1 (GLP-1 and the glucose-dependent insulinotropic peptide, (GIP) the release of which is stimulated by meals. The main action of incretins is to enhance insulin secretion following meals. They are rapidly metabolized in the circulation by the enzyme dipeptidyl peptidase IV (DPP-IV). Patients with type 2 diabetes have markedly impaired... tovább »

Lege Artis Medicinae

NOVEMBER 10, 2008

[UP-TO-DATE MANAGEMENT OF CHRONIC HEPATITIS B]

HORVÁTH Gábor

[Hepatitis B virus infection is a significant health problem worldwide, as well as in Hungary. The chronic infection is usually symptomless, its most dangerous risks are liver cirrhosis and hepatocellular carcinoma. The latter may occur without development of liver cirrhosis, so it means a potential complication for patients with inactive phase of infection, as well. Criteria of the indication of antiviral treatment have changed in the last years due to the flare of our knowledge about the... tovább »

Lege Artis Medicinae

NOVEMBER 10, 2008

[CHANGING STRATEGY IN THE LONG-TERM TREATMENT OF OVARIAN CANCER - ON THE IMPORTANCE OF PLATINUM-FREE INTERVAL]

HERNÁDI Zoltán

[It was during the last 15 years when justified by clinical studies the sensitivity/resistance to anticancer chemotherapy was included in the setting of the prognostic factors of the ovarian cancer, while demonstrating a stronger correlation with the outcome than those factors known before. Remission and duration of remission after first-line chemotherapy are the two important components of sensitivity and their combinations measure its grade in a semi-quantitative manner. The chemotherapy... tovább »

Lege Artis Medicinae

NOVEMBER 10, 2008

[OPTIMIZATION OF PAIN THERAPY BASED ON PHARMACOKINETICS - INNOVATIVE DRUG DELIVERY SYSTEMS]

ANTAL István, KLEBOVICH Imre

[Medicinal preparations with durable analgetic effect are essential for therapy of the chronic pain. Controlling drug release allows the influence of fate of drug in the body as well as prolongation of duration of action. Development of innovative dosage forms as drug delivery systems offers increased efficacy and tolerability to improve patient's quality of life. Beside maintaining continuous therapeutical effect, extended drug release allows the spacing of dosing frequency. In addition, the... tovább »

Lege Artis Medicinae

NOVEMBER 10, 2008

[LOW GRADE FIBROMYXOID SARCOMA OF THE TEMPORALIS MUSCLE - A CASE REPORT]

KOVÁCS S. Krisztián, FAN Rong, MICHALS Edward A., DÓSA Sándor, VILLANO John L., VÁLYI-NAGY Tibor

[INTRODUCTION - Low grade fibromyxoid sarcomas (LGFMS) in most cases arise in the skeletal muscle primarily in young to middleaged adults. Males are affected more commonly than females. The tumour tipically arises in the lower extremities, particularly the thigh. Hyalinizing spindle cell tumor with giant rosettes is a variant of LGFMS that demonstrates a significant overlap with classic LGFMS regarding patient age and tumor location, histological appearance and metastatic potential. CASE REPORT... tovább »

Lege Artis Medicinae

NOVEMBER 10, 2008

Lege Artis Medicinae

NOVEMBER 10, 2008

Lege Artis Medicinae

NOVEMBER 10, 2008

Lege Artis Medicinae

NOVEMBER 10, 2008

Lege Artis Medicinae

NOVEMBER 10, 2008

Lege Artis Medicinae

NOVEMBER 10, 2008