Lege Artis Medicinae

[Selective Memory?]

KAHÁN Zsuzsanna

NOVEMBER 10, 2008

Lege Artis Medicinae - 2008;18(11)

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Lege Artis Medicinae

[CHANGING STRATEGY IN THE LONG-TERM TREATMENT OF OVARIAN CANCER - ON THE IMPORTANCE OF PLATINUM-FREE INTERVAL]

HERNÁDI Zoltán

[It was during the last 15 years when justified by clinical studies the sensitivity/resistance to anticancer chemotherapy was included in the setting of the prognostic factors of the ovarian cancer, while demonstrating a stronger correlation with the outcome than those factors known before. Remission and duration of remission after first-line chemotherapy are the two important components of sensitivity and their combinations measure its grade in a semi-quantitative manner. The chemotherapy sensitivity/resistance approach is based on the observations on ovarian cancer patients treated with platinum based chemotherapy. This agent in repeated adminstrations during the whole course of the disease is still a decisive component of the ovarian cancer chemotherapy. As a consequence there is always “a platinum-free interval”. The prolongation of this platinum-free interval with non-platinum chemotherapy has the potencial of increasing the remission and survival by platinum reinduction administered in the third-line of chemotherapy. In spite of the facts mentioned above, there are centers which prefer the early re-administration of taxan/platinum combination to the prolongation of platinum- free interval and expose their patients to an elevated risk of cumulative, in the first-line non-haematological toxicity.The neurotoxicity can deteriorate the quality of life and the parenchymal laesion of kidneys can prevent further chemotherpy.]

Lege Artis Medicinae

[A Change in Attitude in Rheumatology – The Textbook of Rheumatology Edited by: Gyula Poór]

GAÁL János

Lege Artis Medicinae

[LOW GRADE FIBROMYXOID SARCOMA OF THE TEMPORALIS MUSCLE - A CASE REPORT]

KOVÁCS S. Krisztián, FAN Rong, MICHALS Edward A., DÓSA Sándor, VILLANO John L., VÁLYI-NAGY Tibor

[INTRODUCTION - Low grade fibromyxoid sarcomas (LGFMS) in most cases arise in the skeletal muscle primarily in young to middleaged adults. Males are affected more commonly than females. The tumour tipically arises in the lower extremities, particularly the thigh. Hyalinizing spindle cell tumor with giant rosettes is a variant of LGFMS that demonstrates a significant overlap with classic LGFMS regarding patient age and tumor location, histological appearance and metastatic potential. CASE REPORT - A 76 year-old male presented with a ten-year history of a painless, slowgrowing, hard consistency, left-sided temporal mass. The radiological differential diagnosis included liposarcoma, malignant fibrous histiocytoma and rhabdomyosarcoma. Histopathological examination revealed low grade fibromyxoid sarcoma featuring low cellularity, collagenized areas and alternating myxoid areas, and a focal whorling pattern of tumour cells that were immunoreactive for vimentin, but were negative for S100, CD34, muscle specific actin, desmin and cytokeratin (AE1/AE3). CONCLUSIONS - To the best of our knowledge, this is the first report of low grade fibromyxoid sarcoma involving the temporalis muscle.]

Lege Artis Medicinae

[Smoke-free Europe - what is the next step?]

VADÁSZ Imre

Lege Artis Medicinae

[Documented Agony – Pictures of Ferdinand Hodler]

NÉMETH István

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