Lege Artis Medicinae

[OPTIMIZATION OF PAIN THERAPY BASED ON PHARMACOKINETICS - INNOVATIVE DRUG DELIVERY SYSTEMS]

ANTAL István, KLEBOVICH Imre

NOVEMBER 10, 2008

Lege Artis Medicinae - 2008;18(11)

[Medicinal preparations with durable analgetic effect are essential for therapy of the chronic pain. Controlling drug release allows the influence of fate of drug in the body as well as prolongation of duration of action. Development of innovative dosage forms as drug delivery systems offers increased efficacy and tolerability to improve patient's quality of life. Beside maintaining continuous therapeutical effect, extended drug release allows the spacing of dosing frequency. In addition, the more advantageous dosage regimen may improve the patient compliance during drug therapy. The review focuses on the aspects required to design drug carrier systems with original pharmacokinetic profile based on special pharmaceutical technological methods in order to optimize drug therapy for pain management.]

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