Lege Artis Medicinae - 2008;18(10)

Lege Artis Medicinae

OCTOBER 19, 2008

[VERTIGO IN NEUROLOGICAL DISEASES]

FAZEKAS András

[Peripheral and central vestibular syndromes are characterized by the combination of the four symptoms such as: vertigo, nystagmus, imbalance and nausea. Vertigo is the disturbance of the cortico-spatial orientation. Nystagmus is regarded as a secondary symptom caused by direction specific disequilibrium of the vestibulo- ocular reflex. Imbalance is caused by the abnormal activation of vestibulo-spinal pathways. Nausea is due to the activation of the medullary vomiting center. It is important... tovább »

Lege Artis Medicinae

OCTOBER 19, 2008

[IBANDRONATE IN THE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS]

LAKATOS Péter

[Postmenopausal osteoporosis affects 7-10% of the population of developed countries. During the past decade, a number of new therapeutical modalities have been made available. Among these, bisphosphonates mean the mainstay of medical treatment. Ibandronate belongs to the amino-bisphosphonate group of these drugs. Amino-bisphosphonates act via the mevalonate metabolic pathway, thus, inhibiting protein prenylation. Several clinical studies have shown a significant reduction in the fracture risk... tovább »

Lege Artis Medicinae

OCTOBER 19, 2008

[THE PLEIOTROPIC EFFECTS OF LOSARTAN - THE IMPORTANCE OF DECREASING URIC ACID LEVEL]

CSIKY Botond, MARKÓ Lajos, MOHÁS Márton, CSEH Judit, MIKOLÁS Esztella, SZÍJÁRTÓ István, WITTMANN István

[Nowdays the goal of the antihypertensive treatment is to decrease the cardiovascular risk of the patients by treating the associated diseases and possible hypertensive end-organ damages. Losartan is an antihypertensive drug with all these capabilities and placebo-like side-effect profile. Besides the most important effects of losartan, which are mediated by blocking the angiotensin II. type 1. receptors, it also has other, molecule specific beneficial effects. The most important, well... tovább »

Lege Artis Medicinae

OCTOBER 19, 2008

[ANTI-VEGF THERAPY WITH BEVACIZUMAB IN BREAST CANCER]

TÓTH Judit, GONDA Andrea, SZÁNTÓ János

[The growth of new blood vessels, angiogenesis is important for tumour progression and metastasis. Vascular endothelial growth factor (VEGF) plays multiple roles in cancer development. Due to it the VEGF seems to be an optimal therapeutic target in breast cancer therapy. The plasma level of this growth factor is highest early in disease suggests that anti-VEGF agents may provide their greatest benefit in firts-line chemotherapy with metastatic breast cancer (MBC). A phase III trial, E2100... tovább »

Lege Artis Medicinae

OCTOBER 19, 2008

[THE ROLE OF HYDROMORPHONE IN PAIN KILLING]

TELEKES András

[The hydromorphone is a potent semisynthetic opioid agonist which is available in several forms including injection immediately release or retard tablets. Its analgesic efficacy surpasses morphine. The absorption of oral osmotic retard tablet is independent from food- or alcoholconsumption providing steady plasma concentration by once daily application. The clinical pharmacology of hydromorphone is summarized.]

Lege Artis Medicinae

OCTOBER 19, 2008

Lege Artis Medicinae

OCTOBER 19, 2008

[SEVERE NECROTISING PRIMARY VASCULITIS - CASE REPORT]

GRIGER Zoltán, SZÁNTÓ Antónia, SZABÓ Nóra Anna, SOLTÉSZ Pál, ZEHER Margit

[INTRODUCTION - Vasculitis is an inflammatory disorder of the vessels, often associates with necrosis. The primary (idiopathic) form caused by distinct immunological mechanisms, the secondary form caused by infection, tumor, drugs or systemic autoimmune disease. CASE REPORT - 57-year-old smoking female patient with a medical history of the left ankle fracture. Four days earlier had sore throat, at admission was febrile and generally weak and had severe pain in her lower extremities. Physical... tovább »

Lege Artis Medicinae

OCTOBER 19, 2008

Lege Artis Medicinae

OCTOBER 19, 2008

Lege Artis Medicinae

OCTOBER 19, 2008