Cardiology

Lege Artis Medicinae

OCTOBER 07, 2024

[VI. Szekszárdi Hypertonia Napok]

BENCZÚR Béla

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HUN 2024;34(9)

Clinical Neuroscience

SEPTEMBER 30, 2024

Predictors of pneumonia in stroke patients with dysphagia: A Turkish study

HALIM Ömer KAŞIKÇI, ELIF ÜÇGÜL ERÇİN , RAHŞAN KARACI, MUSTAFA ÜLKER, FÜSUN DOMAÇ MAYDA

Dysphagia, characterized by difficulty in swallowing due to neurological deficits, stands out as the foremost contributor to stroke asso­ciated pneumonia (SAP) development. Recent investigations have explored the utility of blood tests, including parameters like neutrophil count, leukocyte count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the CRP to albumin ratio (CAR), at the time of admission as potential markers for predicting SAP development. This study is set out to assess predictors of SAP in patients with acute ischemic stroke and dysphagia. 

This retrospective cross-sectio­nal study, conducted at the University of Health Sciences, Neurology Department of Erenkoy Mental Health Neurological Disor­ders in Istanbul, Turkey, between January 2021 and January 2023, assessed 65 indivi­duals with acute ischemic stroke and dysphagia. Excluding specific criteria, clinical and laboratory data were collected. Patients were categorized into SAP and non-SAP groups based on diagnostic criteria. Results provide insights into risk factors of SAP.

In this study of 65 stroke patients with dysphagia, 27 (41.5%) developed SAP within the first week. No significant differences in age, gender, comorbidities, or infarct size were observed between the pneumonia-positive and pneumonia-negative groups (p > 0.05). HbA1c levels were significantly lower in the pneumonia-positive group (p = 0.02). Logistic regression revealed that NLR, CAR levels, and the presence of atrial fibrillation (AF) were significant predictors of pneumonia development (p < 0.001).

Dysphagia is considered one of the most significant risk factors for SAP. However not all ischemic stroke patients with dysphagia develop SAP; that is the reason we think NLR, CAR, and AF might be predictors of SAP in acute ischemic stroke patients with dysphagia.

ENG 2024;77(9-10)

Lege Artis Medicinae

SEPTEMBER 06, 2024

[Significance, screening, and effective treatment of lysosomal acid lipase deficiency ]

HARANGI Mariann, HOMORÓDI Nóra

[Lysosomal acid lipase deficiency is a rare lysosomal storage disease with an autosomal recessive inheritance pattern, characterized by altered lipid metabolism and the involvement of several organs, including the liver and the gastrointestinal tract. The cause of the disease is a homozygous or compound heterozygous mutation of the LIPA gene, resulting in significantly reduced activity of the lysosomal acid lipase enzyme encoded by the gene. The severe form that appears in infants is called Wolman’s disease, while the milder, late-onset form is also mentioned as cholesterol-ester storage disease. Wolman's disease has a poor prognosis due to liver failure, severe malabsorption, and adrenal insufficiency. The late onset form of the disease causes mainly fatty liver and lead to gastrointestinal and cardiovascular complica­tions. The diagnostics of the disease the dried blood spot test measuring the en­zyme activity has a particular importance, but it should be confirmed by genetic testing of the LIPA gene. The treatment is currently based on human recombinant en­zyme replacement therapy (sebelipase alfa), which is now also available in Hun­gary. Although the disease is rare, early detec­tion and modern, targeted treatment may improve the life expectancy and quality of life of patients.]

HUN 2024;34(7-8)

Lege Artis Medicinae

SEPTEMBER 06, 2024

[VI. Szekszárdi Hypertonia Napok „A nők egészsége”]

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HUN 2024;34(7-8)

Clinical Neuroscience

JULY 30, 2024

Determination of hemorrhagic transformation risk in acute ischemic cerebrovascular disease: The relationship between ADC values and GRE hemo sequence microhemorrhage

EZGI YAKUPOGLU, FUSUN MAYDA DOMAC

To determine the risk of hemorrhagic transformation in patients with acute ischemic cerebrovascular disease, we investigated the relationship between Apparent Diffusion Coefficient Magnetic Resonance Imaging values measured within the infarct area and microbleeds observed on Gradient Echo Sequence Magnetic Resonance Imaging.

ENG 2024;77(7-8)

Clinical Neuroscience

JULY 30, 2024

Effect of surgical mask and N95 respirator mask use on cerebrovascular reactivity

ASLI YAMAN KULA, SULTAN MEŞE, VILDAN GÜZEL, AYŞEGÜL YABACI TAK, MEHMET YİĞİT, SERDAR BALSAK, TALIP ASİL

Face masks are crucial parts of personal protective equipment (PPE) to reduce the risk of respiratory infections. The COVID-19 outbreak has increased healthcare workers’ use of face masks. This study aimed to evaluate changes in cerebrovascular response among healthcare workers using surgical and N95 respirator masks.  90 healthcare workers: 30 wearing surgical masks, 30 wearing N95 respirators, and 30 without masks were included.

ENG 2024;77(7-8)