Immune Oncology

Clinical Neuroscience

SEPTEMBER 30, 2024

Effect of inflammatory response before mechanical thrombectomy on prognosis in stroke patients

EMRAH AYTAÇ, FERHAT BALGETİR, ŞULE Kavak Genç, MURAT Gönen, HASAN DOGAN, CETIN Kursad AKPINAR

Mechanical thrombectomy is the most important treatment modality in acute stroke; despite successful thrombectomy, good functional outcome is not achieved in a significant proportion of patients. This study examined the effect of neutrophil lymphocyte ratio (NLR) values at admission on functional outcomes in successfully recanalized patients.

ENG 2024;77(9-10)

Clinical Neuroscience

SEPTEMBER 30, 2024

Predictors of pneumonia in stroke patients with dysphagia: A Turkish study

HALIM Ömer KAŞIKÇI, ELIF ÜÇGÜL ERÇİN , RAHŞAN KARACI, MUSTAFA ÜLKER, FÜSUN DOMAÇ MAYDA

Dysphagia, characterized by difficulty in swallowing due to neurological deficits, stands out as the foremost contributor to stroke asso­ciated pneumonia (SAP) development. Recent investigations have explored the utility of blood tests, including parameters like neutrophil count, leukocyte count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the CRP to albumin ratio (CAR), at the time of admission as potential markers for predicting SAP development. This study is set out to assess predictors of SAP in patients with acute ischemic stroke and dysphagia. 

This retrospective cross-sectio­nal study, conducted at the University of Health Sciences, Neurology Department of Erenkoy Mental Health Neurological Disor­ders in Istanbul, Turkey, between January 2021 and January 2023, assessed 65 indivi­duals with acute ischemic stroke and dysphagia. Excluding specific criteria, clinical and laboratory data were collected. Patients were categorized into SAP and non-SAP groups based on diagnostic criteria. Results provide insights into risk factors of SAP.

In this study of 65 stroke patients with dysphagia, 27 (41.5%) developed SAP within the first week. No significant differences in age, gender, comorbidities, or infarct size were observed between the pneumonia-positive and pneumonia-negative groups (p > 0.05). HbA1c levels were significantly lower in the pneumonia-positive group (p = 0.02). Logistic regression revealed that NLR, CAR levels, and the presence of atrial fibrillation (AF) were significant predictors of pneumonia development (p < 0.001).

Dysphagia is considered one of the most significant risk factors for SAP. However not all ischemic stroke patients with dysphagia develop SAP; that is the reason we think NLR, CAR, and AF might be predictors of SAP in acute ischemic stroke patients with dysphagia.

ENG 2024;77(9-10)

Journal of Nursing Theory and Practice

AUGUST 30, 2024

[The Role of Palliative Nurses in the Multidisciplinary Team]

LUKÁCS Miklós

[The author presents the role of the nurse in the practice of hospice-palliative care. The aim of the care is to alleviate the physical, mental, social, spiritual and emotional sufferings and symptoms of advanced cancer patients in Hungary, and to improve their quality of life. As a member of the mandatory multidisciplinary team, the nurse has a significant role in this. The manuscript provides an overview of the tasks and difficulties of hospice nurses in the domestic and international situation.]

HUN 2024;37(4)

Journal of Nursing Theory and Practice

AUGUST 30, 2024

[Aspects of Occupational Health Nursing for Incurable Patients ]

HIRDI Henriett Éva

[The number of individuals diagnosed with cancer among working-age populations is alarmingly increasing, and cancer remains one of the leading causes of death. Over the past few decades, the topic of staying in the labor market has become a worldwide subject of discussion regarding improving the quality of life for employees suffering from terminal illness. In this context, the importance of workplace rehabilitation, a supportive environment, and occupational health care is being increasingly recognized. With appropriate training, occupational health nurses could play a key role in collaborating with affected employees, as they can assist in assessing individual needs and ensuring reasonable accommodations in the workplace. Through their activities, the working conditions designed for terminally ill employees can simultaneously enhance quality of life and enable productive work at the end of life.]

HUN 2024;37(4)

Lege Artis Medicinae

SEPTEMBER 06, 2024

[The mechanisms of targeted pharmacological inhibition of immunopathological processes ]

VERECKEI Edit

[The pathology and clinical presentation of inflammatory rheumatic diseases at tissue and organ level are determined by the signalling of cytokines and their receptors on the cells involved. The cells of the immune system are essentially differentiated to eliminate pathogens and decomposed self structures. The cytokine-driven signal­ling/ trans­duction structure is networked. The induction of the signalling complex may result uncontrolled tissue damage. Some of the cytokines are differentiating, physiological, growth factors, while the protective cytokines excite pro-inflammatory, autoaggressive mediator and effector molecules. Increasing insights into pathological mechanisms are revealing therapeutic targets where these processes can be effectively inhibited. The physicochemical properties of key molecules are enabling the planned development of targeted therapeutics using artificial intelligence. Targeted therapeutics are biological response modifiers, or biologics for short. They are genetically engineered anticytokine macromolecules or small molecule enzyme inhibitors that act as passive vaccines. Targeted therapy is thus a practical example of translational medicine, i.e. the direct applica­tion of the results of scientific research to a therapeutic end. This paper aims to illust­rate this network and therapeutic endeavour.]

HUN 2024;34(7-8)

Clinical Neuroscience

JULY 30, 2024

An update on approved and emerging drugs for the treatment of postpartum depression

ELIF Asena ÇULCU, ŞENIZ DEMİRYÜREK, ABDULLAH Tuncay DEMİRYÜREK

Depression, anxiety and psychotic disorders are common perinatal mental health disorders in the postpartum period. Depressive symptoms that occur postpartum are also present in the prenatal period in 50% of patients. Risk factors for the development of postpartum depression include poor relationship with the partner, lack of social support, mother’s low socioeconomic status and multiparity.

ENG 2024;77(7-8)