The eLitMed.hu medical portal uses computer cookies for convenient operation. Detailed information can be found in the Cookie-policy.
Lege Artis Medicinae - 1992;2(03)
Content
Lege Artis Medicinae
MARCH 31, 1992
[A newly discovered vasoconstrictor peptide: endothelin]
[The discovery of endothelium-derived relaxing (prostacyclin, EDRF) and contracting factors (EDCF) in the last decade opened up new vistas in investigating the regulation of the cardiovascular system. In this review, recent results of the research of a 21 amino acid residue EDCF, called Endothelin, including its discovery, isolation, biosynthesis, tissue specific expression, receptors and the characteristics of the Endothelin converting enzyme are summarized. Based on present knowledge of the wide variety of biological actions of Endothelins, we present their possible autocrine, paracrine and humoral actions, and their significance in the physiological regulation of the cardiovascular system as well as in pathological conditions. Despite the abundance of information however, the actual role of Endothelins in the short- and long-term modulation of the tissue function still remains to be determined.]
Lege Artis Medicinae
MARCH 31, 1992
[ATP-sensitive potassium channels, and their modulators]
[Recently great interest has been concentrated on potassium channels inhibited by intracellular adenosine triphosphate (ATP-sensitive potassium channels), which connect the metabolic state of cells with their electrical activity. Channel closure initiates the secretion of insulin from pancreatic ß-cells; a number of hormones altering the level of blood-sugar act via these channels. The channels are present in neurones; they regulate both in the cell bodies and the nerve terminals (e. g. peripheral nerves) the excitability. The reby, in the central nervous system, they influence the neuronal activity both in the satiety center and some catecholaminergic brain nuclei. These channels mediate the effects of endogenous vasodilators in vascular smooth muscle. They have a pathophysiological role in protecting neurones and muscle cells from hypoxic damage. The ATP-sensitive potassium channels are targets of the sulphonylurea antidiabetic agents and of a new class of drugs, the potassium channel agonists. The latter compounds are investigated or used for the treatment of hypertension, angina pectoris, cardiac insufficiency, bronchial asthma, irritable bladder syndrome, chronic occlusive arterial disease and even in impotence. They are relatively well-tolerated drugs. Their adverse effects are related to their basic vasodilator profile and most commonly include headache, dizziness, palpitation or oedema. ]
Lege Artis Medicinae
MARCH 31, 1992
[Native CT examination of the intraarticular ligaments of the knee joint]
[The high incidence of intra-articular ligament injuries of the knee justifies a more frequent use of noninvasive diagnostic procedures such as the native CT scan. In positive cases, a correct preoperative diagnosis may be produced; a negative result is especially important, since diagnostic arthroscopy may be avoided. Due to the anatomic arrangement of the knee joint ligaments and theis density, which differentiates them from adjacent structures, an accurate, reliable, and reproducible image can be obtained with the native CT scan. With the high resolution charactaristic of the native CT scan, the ligaments of Humphry and Wrisberg can be visualized, and the two bundles of the anterior cruciate ligament can be distinguished from one another. Exact localization of intra-articular ligament rupture is essential in the planning of an optimal treatment schedule. According to the literature and the authors experience, the native CT scan is equivalent to the MRI as a diagnostic procedure in knee intra-articular ligament lesions. It has the advantage of being far less expensive and it is presently available in Hungary. ]
Lege Artis Medicinae
MARCH 31, 1992
[Dipyridamole test: comparative evaluation of simultaneous 2D echocardiography and 201TL scintigraphy in ischaemic heart disease]
[Simultaneous 2D echocardiography and 2017 scintigraphy were performed during dipyridamole testing (DT) in 57 patients with suspected IHD. The dipyridamole dose was 0.56 mg/kg/bm in 4 minutes. If no effect was observed, the test was continued from the eighth minute with a dose of 0.28 mg/kg/bm in 2 minutes. 2D echomonitoring of the left ventricular motion using apical views was initiated at the beginning of DT and continued for 7 or 13 minutes in case of the longer test. After 6.5 or 12.5 minutes, 74 MBq 201TI was injected intravenously. Standard planar scintigraphy was performed in 3 views starting within 15 minutes. On the basis of the clinical results, 25 patients were subsequently referred for coronary angiography. The sensitivity, specificity and positive and negative predictive values of 2D echocardiography were 79%,55%,69% and 67%, respectively. The corresponding values for 201TIscintigraphy were 93%, 27%, 62%, and 75%. Where the results of both methods were positive, the combined sensitivity and specificity values were 71% and 73%. The results indicate the suitability of both methods for detecting IHD. Furthermore, they suggest a higher specificity, but lower sensitivity of 2D echocardiogaphy as compared to 201TI scintigraphy. Our observations demonstrate that the com binaton of these 2 techniques is very useful in clinical practice for the evaluation of IHD.]
Lege Artis Medicinae
MARCH 31, 1992
[Multiple Risk Factor Intervention Trial]
[The aim of the study: to investigate whether a multi-risk factor programme can reduce coronary heart disease mortality.]
Lege Artis Medicinae
MARCH 31, 1992
[Dipyridamole-thallium scintigraphy]
[Thallium 201 myocardial scintigraphy; Dipyridamole-thallium scintigraphy; Test schedule; Expected results; Side effects; Advantages and disadvantages of D-TI201; Method modifications; Adenosine-thallium scintigraphy]
Lege Artis Medicinae
MARCH 31, 1992
[Thoracic sympathectomy using laparoscopic devices]
[Thoracic sympathectomy is beneficial in the treatment of peripheral occlusive arterial T 1 circulatory disorders of the upper limb (Buerger's disease, Raynaud's disease) and palmar and axillary hyperhidrosis (1-3). In 1987, Sebestyén and colleagues described it in Hungary (4). We have been performing laparoscopic surgery in our clinic since 1990, and in 1991 we performed thoracic sympathectomies using laparoscopic instruments. ]
Lege Artis Medicinae
MARCH 31, 1992
[Fiberscopic examination of posttracheotomy tracheae in myasthenic patients]
[Posttracheotomy strictures are often detectable only long after decannulation. That observation led the authors to make endoscopic follow-up examination of the tracheae of tracheotomized patients. Since 1973, 103 of 600 myasthenic thymectomized patients required tracheotomy. 45 of them were examined with fiberscope under topical anesthesia two months to thirteen years after tracheotomies (47 cases). The tracheal lumen was expressed as an estimated percent age of the original cross section. Strictures of various sizes were detected in 33 cases (70%), of which 5 (11%) were symptomatic. The stridor of two patients was eliminated by the resection of nodular struma which were causing compression, and by the removal of granuloma formed at the site of the stoma. In three cases of verified stricture, repeated translaryngeal intubation was performed under optical control. In regular follow-up patients prefer fiberscopy to the rigid bronchoscopy. In addition, fiberscopy reveals severe strictures causing stridor and significant, but asymptomatic, stenoses. The awareness of these changes is essential in the management of myasthenic patients. Based on their own clinical experience, the authors suggest a follow-up protocol. ]
Lege Artis Medicinae
MARCH 31, 1992
[Evaluation of mutations in cystic fibrosis]
[The frequency of the most common mutations of the CFTR gene was studied in families having children with cystic fibrosis. This study included 40 Hungarian families with a total of 140 family members. The results of mutation and haplotype analysis demonstrate that the most frequent mutation in the Hungarian cystic fibrosis population is the F508 which accunts for 70% of all the mutations. The most frequently occurring haplotype is B: 95,7% of the F508 CF chromosomes and 36% of the non-F508 chromosomes are associated with the haplotype B (KM-19: allele 2, XV-2c: allele 1). The molecular genetic analysis of CF families based on the study of the CFTR gene's mutations makes possible an improved prenatal diagnosis in high risk pregnancies. ]
Lege Artis Medicinae
MARCH 31, 1992
[Questions in developing the public health information system]
[The tasks of the Public Health Service and the Medical Officer Service go far beyond the classical public health epidemiological system, to include prevention of public health endangering conditions and life threatening diseases. The Public Health Service is competent to supervise the efficient operation of the healthcare institution. Optimal operation of the system requires the use of an information system relying on modern computer technology. Conceptually, the information system is people-centered. Is is based on a flexible modular structure with multiple functions, according to the functions of the service. It consists of a network of divided data bases in order to provide relation data services. ]
Lege Artis Medicinae
MARCH 31, 1992
[Reflections on Life Science in a study]
[Physiology: the approach; The institutional network; The teaching of physiology; The functions of the Physiological Society; Science universal; Research at home?; ]
Lege Artis Medicinae
MARCH 31, 1992
[The hospital quality assurance system ]
[A significant part of the phenomena of the health care crisis in our country is due to the haphazard, disorganised and often non-existent nature of controls. A key objective of the planned reform processes is therefore to renew and consolidate it. ]
Lege Artis Medicinae
MARCH 31, 1992
[Should he who changes his country, change his heart?]
[I have slightly twisted Mihály Tompa's immortal line: 'Let him exchange hearts who exchanges homeland I'. The poet could hardly have imagined that his heartbreaking metaphor would become flesh and blood reality a century later, because it is possible to exchange hearts. In fact, twenty years after the first heart transplant, a Hungarian heart can be exchanged for a Hungarian heart; the heart of one unfortunate man can save another unfortunate young man.]
Lege Artis Medicinae
MARCH 31, 1992
[Can we get from the denominator to the numerator?]
[There were many good reasons why Csaba Fáklya (SZDSZ), in the context of the Hungarian Medical Chamber's resolution on the reform, requested that members of the Parliament's Social Committee meet with members of the Presidency and a representative of the Ministry of Public Welfare. One of the most important issues for them is the isolation of MPs from life. They go from committee to plenary, from group meetings to political meetings. Their reading is nothing more than the tabling of motions, the related expert and background material, and the newspapers they read during plenary sessions. What else can they do but call on those who can inform them.]
Lege Artis Medicinae
MARCH 31, 1992
[Position of the Hungarian Medical Chamber on the planned healthcare reform]
[In the summer of 1991, the National Welfare Board announced and published in the specialised press its action programme for the transformation and renewal of the health sector. Even at the time of its publication, the programme contained a number of controversial theses, but it was unanimously welcomed by the medical community, which was interested in the creation of a new type of health care system.]
Lege Artis Medicinae
MARCH 31, 1992
[In crisis]
[On the eighteenth day of December last year, László Surján, Minister of National Welfare, proudly reported to the Parliament of the Republic of Hungary that, "I think back to a year ago, when the budget debate in Parliament and the debate on the Social Security Fund budget were significantly out of sync in time. At the time, those of us who were and those who were not guilty of this were all disapproving of the fact that this situation had arisen. This year we managed to present the two budgets to the House at the same time."]
Lege Artis Medicinae
MARCH 31, 1992
[About the General Assembly of the Medical Chamber]
[The Minister's speech is reproduced from the minutes of the Assembly. The text has been condensed and the eventualities of live speech have been adapted to the requirements of the written word.]
Lege Artis Medicinae
MARCH 31, 1992
[On the concept of individual and social health Part II.]
[Health as the capacity for ideal functioning; Sociocultural definition of health; Summary; ]
Lege Artis Medicinae
MARCH 31, 1992
[Medical advertising]
[Medical history is full of documents that show the inexhaustible ideas of doctors who wanted to increase the number of their patients. Sometimes this included discrediting colleagues or simply promoting themselves. Let us look at some examples.]
Lege Artis Medicinae
MARCH 31, 1992
[Fasciculus medicinae]
[The colour woodcut on the title page or another illustration from the Fasciculus medicinae, a medical aid book published in several editions around 1500, is found in almost every major compilation of European medical history and art history.; Collection of medical writings; New edition - new illustrations; The most important scene;]
Lege Artis Medicinae
MARCH 31, 1992
[WHO Regional Office symposium]
[In difficult times, it is good to know that we are not alone. Our health system in crisis and your reform efforts are not lonely, as the health system war is raging - albeit at different levels - across Europe, across the world.]
Lege Artis Medicinae
MARCH 31, 1992
1.
Clinical Neuroscience
[Headache registry in Szeged: Experiences regarding to migraine patients]
21. MAY
2.
Clinical Neuroscience
[The new target population of stroke awareness campaign: Kindergarten students ]
21. MAY
3.
Clinical Neuroscience
Is there any difference in mortality rates of atrial fibrillation detected before or after ischemic stroke?
27. NOV
4.
Clinical Neuroscience
Factors influencing the level of stigma in Parkinson’s disease in western Turkey
27. SEP
5.
Clinical Neuroscience
[The effects of demographic and clinical factors on the severity of poststroke aphasia]
18. JUL
1.
2.
Clinical Oncology
[Pancreatic cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up]
29. AUG
3.
Clinical Oncology
[Pharmacovigilance landscape – Lessons from the past and opportunities for future]
29. AUG
4.
5.