This review article takes a closer look at the management of Glioblastoma Multiforme (GBM) in elderly patients, with particular focus on treatment outcomes and prognostic indicators. The study findings reflect that advanced age in GBM patients often corresponds with lower survival rates, higher treatment-related toxicity, and challenges in achieving complete surgical resection. Also noteworthy is the reduced likelihood of elderly patients receiving adjuvant therapy and the distinct molecular and genetic profiles that may guide personalized therapeutic interventions. While these insights provide some understanding of GBM’s unique characteristics in older patients, they also highlight the need for further research and development of age-specific treatment guidelines to improve patient outcomes. The insights offered in this review should prove useful to healthcare professionals caring for this population, although further research is needed to corroborate and expand upon these findings.