Lege Artis Medicinae - 2010;20(10)

Lege Artis Medicinae

OCTOBER 20, 2010

Lege Artis Medicinae

OCTOBER 20, 2010

[Connection between fetal development and adult diseases - Long acting effects of stress affecting the mother and the fetus]

MOLNÁR Ildikó

[The stress responses affecting the mother and the fetus have a life-long consequence in the manifestation of adult metabolic disorders. The perinatal stress inducing fetal adaptation contributes to alterations in tissue structures and hormone regulations as well as could lead to intrauterine growth retardation. The newborns with low birth weight are associated with the glucocorticoid, adrenaline and insulin resistance making them postnatal susceptible to obesity, diabetes type 2 and... tovább »

Lege Artis Medicinae

OCTOBER 20, 2010

Lege Artis Medicinae

OCTOBER 20, 2010

[Carvedilol and its antioxidant effect]

KOVÁCS Imre

[Carvedilol, the typical basic variant of the third generation beta blocker drugs is a complex adrenergic blocker that also has Ca channel blocking effects. It has no effect of the metabolism and has a pregnant antioxidant effect that is significant for cardiac and hypertension target organ protection. Its beneficial effect on cardiac decompensation, on target organ protection in patients with hypertension and on primary and secondary prevention of ischemic heart disease is proven by clinical... tovább »

Lege Artis Medicinae

OCTOBER 20, 2010

[A new DPP-IV inhibitor: saxagliptin]

KIS János Tibor, MÉSZÁROS Gabriella

[Saxagliptin is a selective, potent inhibitor of dipeptidyl peptidase-IV (DPP-IV). By inhibiting DPP-IV, saxagliptin reduces the degradation of endogenous incretin hormones, resulting in increased glucose-dependent insulin and decreased glucagon secretion from the pancreas islets. Clinical trials of saxagliptin as monotherapy and as combination therapy with other oral antidiabetic medications including metformin, glibenclamide, glipizide, pioglitazone and rosiglitazone have demonstrated... tovább »

Lege Artis Medicinae

OCTOBER 20, 2010

[Concomitant occurrence of multiple myeloma and diffuse large B-cell lymphoma]

RADVÁNYI Mónika, ILLÉS Árpád, MÉHES Gábor, KAJTÁR Béla, FAZAKAS Ferenc, GARAI Ildikó, GERGELY Lajos

[We report a case of a 50-year-old male patient, in whom the coexistence of multiple myeloma and diffuse large B cell lymphoma was confirmed. In December 2007, the patient was admitted to the department of internal medicine with fatigue resulting from mild anemia. A tumor of the left testis was discovered, and after semicastration diffuse large B cell lymphoma was diagnosed by histopathological analysis (clinical stage: II/EB). Examination of the bone marrow revealed a plasmocytic infiltrate of... tovább »

Lege Artis Medicinae

OCTOBER 20, 2010

[Postmenopausal changes of immune system-related genes expression in human bone tissue]

BALLA Bernadett, KÓSA P. János, KISS János, PODANI János, TAKÁCS István, LAZÁRY Áron, BÁCSI Krisztián, NAGY Zoltán Zsolt, SPEER Gábor, LAKATOS Péter

[INTRODUCTION - The molecular and cellular interactions between the immune system and bone tissue have been established. Sex hormone deficiency at the time of menopause has multifunctional role by influencing growth, differentiation and metabolism of the skeletal and the immune system. We have used non-parametric and multidimensional expression pattern analyses to determine significantly changed mRNA profile of immune system-associated genes in postmenopausal (POST) and premenopausal (PRE)... tovább »

Lege Artis Medicinae

OCTOBER 20, 2010

[Pancreatic carcinoma mimicking primary retroperitoneal fibrosis]

RÉDEI Csaba, ESZES Noémi, HAJNAL Péter, MÁTÉ Miklós, SIMON Károly, TÓTH Julianna, POZSÁR József, TOPA Lajos

[INTRODUCTION - One of the defining feature of pancreatic ductal adenocarcinoma (PDA) is the presence of extensive desmoplasia. The volume of stroma production can be disproportionate relative to mass of the tumor. Primary retroperitoneal fibrosis (PRF) is characterized by progressive accumulation and spread of connective tissue in the retroperitoneal space often leading to entrapment of ureters and/or the distal part of the duodenum. The large amount of stroma can mimic the radiologic features... tovább »

Lege Artis Medicinae

OCTOBER 20, 2010

[Why are the screening facilities in Hungary unexploited?]

DÖBRŐSSY Lajos, KOVÁCS Attila, DÖBRŐSSY Bence, BUDAI András, BONCZ Imre, MARGITAI Barnabás, KOÓS Tamás

[In Hungary, as a component of the National Public Health Programme, the “supply side” of the organised mass screening for early detection of some cancers has been established which would be capable of carrying out - in time periods set by the state-of-the-art - the regular screening of the population eligible by age. Unfortunately, the stated objectives of the programme have not fulfiled because the “demand side”, that is the compliance of the target population with the offered screening has... tovább »

Lege Artis Medicinae

OCTOBER 20, 2010