Lege Artis Medicinae

[A new DPP-IV inhibitor: saxagliptin]

KIS János Tibor1, MÉSZÁROS Gabriella2

OCTOBER 20, 2010

Lege Artis Medicinae - 2010;20(10)

[Saxagliptin is a selective, potent inhibitor of dipeptidyl peptidase-IV (DPP-IV). By inhibiting DPP-IV, saxagliptin reduces the degradation of endogenous incretin hormones, resulting in increased glucose-dependent insulin and decreased glucagon secretion from the pancreas islets. Clinical trials of saxagliptin as monotherapy and as combination therapy with other oral antidiabetic medications including metformin, glibenclamide, glipizide, pioglitazone and rosiglitazone have demonstrated clinical benefits in different glycaemic endpoints. Due to its glucose- dependent mechanism of action, saxagliptin as monotherapy or in combination with metformin results in a very low risk for hypoglycemia. It has also been shown to be generally well-tolerated, with not having any relevant effect on weight. The authors summarize the most important saxagliptin trials.]

AFFILIATIONS

  1. Budai Irgalmasrendi Kórház, Belgyógyászati Osztály
  2. Bristol-Myers Squibb Kft.

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