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Lege Artis Medicinae - 2000;10(09)
Content
Lege Artis Medicinae
SEPTEMBER 01, 2000
[Bacteriophage therapy and prophylaxis; Renewal of earlier expectations]
[Bacteriophages were discovered 84 years ago by the observation of a lysis of a bacterial culture. The aim of the earliest attempts was the therapeutic employment of bacteriophages. The experiments controlled unsatisfactorily, could not fulfill expecations and successful antibiotic testing resulted the rejection of bacteriophage therapy. Bacteriophages gained importance in biology in the 1950s, as model viruses in biological and genetic research. The decrease in the success of antibiotic therapy caused to renew efforts in experimental phage therapy. The author reviews the early studies carried out mainly on animals as well as human experiments with bacteriophages purified by genetic methods. According to the results, bacteriophage therapy may be effective under certain circumstances for the infections not treatable by antibiotics, and in the case of antiobiotic-susceptible bacteria it can supplement therapy.]
Lege Artis Medicinae
SEPTEMBER 01, 2000
[Newly discovered molecules the chemokines]
[Chemokine research in the last decade has provided new results in several areas of biomedicine. Investigation and characterization of chemokines resulted in better understanding and modeling complex pathophysiological and immunological processes. Chemokine research opened up entirely new aspects on the defense against pathogenic agents as well as on the processes of inflammation and angiogenesis. With the amount of clinical data growing steadily, it is clear that chemokines could play very important role not only in solving the problems of the oretical and experimental biology but also with their application in clinical diagnostics and therapy. ]
Lege Artis Medicinae
SEPTEMBER 01, 2000
Lege Artis Medicinae
SEPTEMBER 01, 2000
[Effect of calcium channel blocking drugs on the periodontal status of hospitalised patients]
[Ca2+-channel blockers play crucial role in the chronic treatment of hypertension and cardiac arrhythmia. One of the side effects of the chronic nifedipine treatment is gingival enlargement. The pathomechanism of this side effect is not fully understood. The main objective of the present study was to evaluate the potential role of different factors in the development and severity of gingival hyperplasia. The incidence and severity of gingival enlargement were examined around the six surfaces of all fully erupted teeth in 243 hospitalized patients with the modified Angelopoulus-Goaz Gingival Hyperplasia Index. 172 patients in the study group were on Ca2+ channel blockers for at least three months prior to the examination while 71 inpatients served as controls. Gingival hyperplasia occurred in 87% of the test group and in 53% of the control group. Severe gingival enlargement occurred in 35% in the test group and only in 2% of the control group. The age and gender of the patient, the daily dose of the medication, the duration of the administration of the drug showed no correlation with the extent and severity of gingival hyperplasia. Only oral hygiene showed statistically significant correlation with the severity of gingival enlargement. The only clinical parameter influencing the extent and severity of gingival enlargement associated with Ca2+-channel blocker drugs was the quality of oral hygiene. ]
Lege Artis Medicinae
SEPTEMBER 01, 2000
Lege Artis Medicinae
SEPTEMBER 01, 2000
[The treatment of life-threathening ventricular tachyarrhythmias in coronary artery disease - Antiarrhythmic drug or implantable cardioverter-defibrillator?]
[Sudden cardiac death due to sustained ventricular tachyarrhythmias accounts for approximately 50% of all cardiovascular deaths. From the major therapeutic options currently available, antiarrhythmic drug therapy and implantation of automatic car dioverter-defibrillators could be applied to the great majority of patients. Both early observations on automatic implantable cardioverter-defibrillator devices and more recent prospective, randomized, multicenter trials with long-term outcome data uniformly document sudden cardiac death recurrence rates of 1% to 2% annually, compared with recurrences rates of 15% to 25% without the device. There is now compelling evidence from studies suggesing that these devices are superior to antiarrhythmic drugs (Class I and III), both in terms of effectivity and life-saving effects. The implantation of the automatic cardioverter-defibrillator device is currently the first choice therapy for cardiac arrest survivors based on the AHA/ACC guideline (1998), and has to be considered in each case. In the future, the common, hybride treatment with antiarrhythmic device and drugs is expected. ]
Lege Artis Medicinae
SEPTEMBER 01, 2000
[Stress adaptation of te myocardium in the presence of systemic disorders]
[Effective therapeutic strategies for protecting the ischemic myocardium are much sought after. Ischemic heart disease in humans is a complex disorder often associated with other systemic diseases such as dyslipidemia, hypertension and diabetes mellitus exerting multiple biochemical effects on the myocardium. Ischemic preconditioning of myocardium is a well-described adaptive response where brief exposure to ischemia markedly enhances the ability of the heart to tolerate a subsequent ischemic episode. The underlying cellular and molecular mechanisms of pre conditioning have been extensively investigated in the hope of identifying new therapeutic approaches for the protection of the ischemic myocardium. However, most studies have been undertaken in animal models where ischemia was applied in the absence of other diseases, therefore the clinical relevance is questionable. In this article, we review different ways how systemic disease could modify preconditioning response and we also emphasise the importance of further pre-clinical studies for the specific examination of preconditioning in the presence of other complicating disease. ]
Lege Artis Medicinae
SEPTEMBER 01, 2000
[Ischemic preconditioning of the myocardium; The clinical experience]
[The authors give an account of the pathomechanism of ischemic preconditioning. This complex adaptation is achieved by the joint compliance of perfusion, metabolism, function and morphology. The process is triggered by repeated ischemic attacks when transmitter substances are liberated during ischemia, as seen in previous experiments. These modulators are the possible substrates of pharmacologic preconditioning. The principle of parallel treatment of perfusion and metabolism is reviewed with its clinical importance. The clinical manifestations of ischemic preconditioning and the pharmacological approach to mimic preconditioning in the clinical setting are discussed. It is established, that the self-repair mechanisms of the organism can not prevent grave macroangiopathy with its consequences. Persisting ischemia during preconditioning signals the necessity of urgent clinical examinations and effective treatment. By saving time with myocardial adaptation, there will be good chance for the patient to have a successful revascularisation intervention.]
Lege Artis Medicinae
SEPTEMBER 01, 2000
Lege Artis Medicinae
SEPTEMBER 01, 2000
Lege Artis Medicinae
SEPTEMBER 01, 2000
[ Gratitude money in Hungarian healthcare; Who, to whom, why, how much?]
[In the last year, it was brought to life almost at the same time Minister of Health, the so-called Thanksgiving Committee, and began research - commissioned and supported by the Central European University and the State Treasury - by Tárki (Géza Bognár and Róbert Iván Gál, supervisor János Kornai). The studies summarizing the results of the two programs also became known at almost the same time (the report of the Thanksgiving Committee has since been published in book form by Springer Publishing). In our series, we browse in parallel a Commission report focusing on theoretical approaches and a study based on sociological facts (public and medical opinions, data disclosure).]
Lege Artis Medicinae
SEPTEMBER 01, 2000
[ Healing by Jesus and faith]
[Today’s doctors face a wide variety of challenges. They are expected to be accurate, to do everything regularly and precisely, all of course in such a way that they are never mistaken. Many times we want doctors to reap a final and total victory over death. However, this is still not possible. Why did this happen? What is the reason that today’s doctor is expected to do the impossible?]
Lege Artis Medicinae
SEPTEMBER 01, 2000
Lege Artis Medicinae
SEPTEMBER 01, 2000
Lege Artis Medicinae
SEPTEMBER 01, 2000
1.
Clinical Neuroscience
[Headache registry in Szeged: Experiences regarding to migraine patients]
21. MAY
2.
Clinical Neuroscience
[The new target population of stroke awareness campaign: Kindergarten students ]
21. MAY
3.
Clinical Neuroscience
Is there any difference in mortality rates of atrial fibrillation detected before or after ischemic stroke?
27. NOV
4.
Clinical Neuroscience
Factors influencing the level of stigma in Parkinson’s disease in western Turkey
27. SEP
5.
Clinical Neuroscience
[The effects of demographic and clinical factors on the severity of poststroke aphasia]
18. JUL
1.
2.
Clinical Oncology
[Pancreatic cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up]
29. AUG
3.
Clinical Oncology
[Pharmacovigilance landscape – Lessons from the past and opportunities for future]
29. AUG
4.
5.