Lege Artis Medicinae

[Conference report: XXI. Annual Meeting of the Hungarian Psychiatric Association]

BRYS Zoltán, KAPÓCS Gábor

FEBRUARY 12, 2017

Lege Artis Medicinae - 2017;27(01-02)

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[Behavioral therapy of diabetes mellitus]

SAL István, KOHLNÉ Papp Ildikó

[Diabetes is a model disease of behavior therapy. Its treatment is in the hands of patients for the most part, who must make decisions about their treatment every day, which affect their health status, prognosis and risk of developing complications of the disease. This common and complex treatment represents a significant burden for the majority of patients. In practice, a significant number of patients do not follow one or more cornerstones of self-management: physical activity, healthy diet, and use of medication. Based on research results diabetic patients' quality of life and psychological state is significantly worse than those of non-diabetics, which tend to deteriorate the medical collaboration and health status. In addition, certain psychiatric disorders (depression, anxiety, eating disorders), are also more common, which impair the quality of self-treatment as well. Early detection and treatment is of great importance, but in practice, only 10% of patients get psychological treatment, despite the fact that nearly 40% of them experience psychological symptoms. Based on the above, behavior remedial methods are highly recommended to be applied in the field of diabetes care in order upgrade quality of life, although they are not yet considered as commonly accepted in psychoeducation. Our aim is to summarise the practical and proven methods of behavioral remedies in addition to the literature review. In the case study demonstrate the authors the addition of transtheoretical model. The first order condition of self-management is the adoption of the disease and motivation, afterwards comes the teaching of theoretical and practical knowledge, and the ongoing diabetes education. ]

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We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

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Lege Artis Medicinae

[LAM 30: 1990–2020. Facing the mirror: Three decades of LAM, the Hungarian medicine and health care system]

KAPÓCS Gábor