Lege Artis Medicinae - 2011;21(10)

Lege Artis Medicinae

OCTOBER 20, 2011

Lege Artis Medicinae

OCTOBER 20, 2011

[Pulmonary arterial hypertension in systemic autoimmune diseases]

VÉGH Judit, ZEHER Margit

[Pulmonary arterial hypertension is a rare disease, but it occurs more often in systemic autoimmune diseases, where it represents one of the most severe, life-threatening complications. Its development is due to an immunoregulatory disorder characteristic to systemic diseases, persistent inflammation and the subsequent endothelial dysfunction, the presence of pathogenic autoantibodies, smooth muscle cell dysfunction and complex angiogenetic disorder. As a consequence of endothelial cell... tovább »

Lege Artis Medicinae

OCTOBER 20, 2011

[Perioperative management of patients with coronary stent in case of interventions other than cardiac surgery - Part I. - Perioperative treatment of patients with coronary stent]

ZIMA Endre, MEZŐFI Miklós, BECKER Dávid, SZABÓ György, MERKELY Béla, PÉNZES István

[Percutaneous coronary intervention (PCI) is meant to optimalise cardiac status, that is, short-term and long-term outcomes. It is known from large Western databases that stent implantation is performed in 77-85% of coronary interventions, which means hundreds of thousands of new patients with stent every year. The great majority of these patients has to take platelet aggregation inhibitors, namely acetylsalicylic acid and thienopyridin, most often clopidrogel. It presents a major therapeutic... tovább »

Lege Artis Medicinae

OCTOBER 20, 2011

[How diabetogenic is statin therapy?]

CSÁSZÁR Albert

[According to the latest guidelines, the goal in cardiovascular prevention is to achieve an LDL-cholesterol level no higher than 1.8 mmol/l in the high risk and extra high risk groups. According to international recommendations, statin should be used at the highest tolerable dose rather than any combination treatments. In a number of cases, higher doses are associated with increased side effects, which rarely affect liver enzymes and CK-parameters. A metaanalysis published in 2011 made it clear... tovább »

Lege Artis Medicinae

OCTOBER 20, 2011

[Pycnogenol in the clinical practice of French maritime pine bark extractum]

KISS István, TAVASZY Mariann, FARSANG Csaba

[Polyphenols, which belong to the group of flavonoids, can be found in a number of plants, and are present in a high concentration in the French maritime pine bark. The authors summarise results of large-scale experimental and clinical studies on pycnogenol, the standardised extract of French maritime pine bark. Pycnogenol decreases production and effects of free radicals (antioxidant effect). It has antiinflammatory properties, and, by the stimulation of eNOSsynthesis, it increases the... tovább »

Lege Artis Medicinae

OCTOBER 20, 2011

[Neurological effects of tolperisone]

KOVÁCS Tibor

[Spasticity, as a result of cortical motor neuron injury, is a frequent symptom in neurological disorders. Tolperisone is a centrally acting muscle relaxant, which has been used for 50 years in clinical practice. Tolperisone has a membrane-stabilising effect and it inhibits voltage-gated sodium and calcium channels. Although it targets the central neural system, it has no sedative side effects, in contrast to other muscle relaxants. Besides clinical experiences of past decades, the efficacy of... tovább »

Lege Artis Medicinae

OCTOBER 20, 2011

[Antidiabetic therapy of patients with type 2 diabetes mellitus - The place of insulin administration]

GYIMESI András

[Nowadays numerous options to treat diabetes are available, and it is often difficult to choose the optimal treatment. This review summarises the options regarding insulin therapy of type 2 diabetes, in order to help the better management of patients in the everyday clinical practice.]

Lege Artis Medicinae

OCTOBER 20, 2011

[Societal burden of blindness in Hungary]

NÉMETH János, NAGYJÁNOSI László, NAGYISTÓK Szilvia, TOLNAYNÉ Csattos Márta, SZABÓNÉ Berta Irén, KINCSE Éva, SZULYÁK Eleonóra, BOÉR Ibolya, HUNDZSA Gyula, KALÓ Zoltán, BERTA András

[OBJECTIVES - Blindness represents a significant health and economic burden worldwide as well as in Hungary. The aim of this research was to estimate medical and nonmedical expenses related to blindness of elderly patients (>60 years) in Hungary so that the results can be used for further analyses. METHODS - The data required for determining the socioeconomic burden of disesase were derived from the published literature, statistical databases and estimations of relevant experts. We divided the... tovább »

Lege Artis Medicinae

OCTOBER 20, 2011

[Examination of the efficacy of clopidogrel-hydrogen-sulphate in patients with cerebrovascular disease]

SZAPÁRY László, FEHÉR Gergely

[INTRODUCTION - On the basis of current guidelines, acetylsalicylic acid plus dipyridamole or clopidogrel monotherapy should be used for the long-term treatment of patients with cerebrovascular disease, whereas acetylsalicylic acid monotherapy is not recommended. The efficiency of recently introduced generic clopidogrels has not been assessed in patients with a history of acute stroke. PATIENTS AND METHODS - 100 patients with a history of acute stroke or transient ischaemic attack were involved... tovább »

Lege Artis Medicinae

OCTOBER 20, 2011