[The main role of atherogenic dyslipidemia is known for decades. Several studies have proven the beneficial effect of statin therapy on cardiovascular morbidity and mortality. The following case report demonstrates the efficacy of high dose statin therapy regarding lipid goals and clinical signs. The presented 65 year-old female patient had a history of dyslipidemia and hypertension for over 15 years and positive cardiovascular family history. Carotid ultrasound examination showed 15-20% bilateral stenosis in 2008 whereas four years later, control ultrasound showed significant progression with 65% left-sided asymptomatic stenosis. At this time, LDL-cholesterol level was above the target; we managed to reach the recommended level with high-dose statin treatment in combination therapy with ezetimibe. Besides the lipid levels, regression of the carotid stenosis could be observed without statin-associated side effects.]

[Background - There are still dilemmas about the vasodilating effect of vinpocetine, a synthetic ethyl alkaloid vincamine. The method of measuring cerebral vasomotor reactivity (VMR) by transcranial Doppler (TCD) technique before and after administration of the medication was used to estimate the degree of arterioles vasodilatation. The aim of this study was to test of the vasodilating effect of vinpocetine in patients with cerebral small vessel disease (SVD) by measuring cerebral VMR. Material and methods - Thirty patients with SVD were on 3-month-long oral treatment with 15 mg vinpocetine daily. Cerebral VMR was determined by breath holding test. The breath holding index (BHI) was calculated in standard manner and values >0.69 were considered normal. At the baseline, before treatment (I), BHI, modified Rankin scale (mRS) score, Mini Mental State Examination (MMSE) score were determined. One month later (II) BHI was assessed again, while after 3 months of treatment (III) we analyzed BHI, mRS score and MMSE score. Results - The average age of patients was 61.4±11.5 years (range 40 to 77 years), 18 (60%) female and 12 (40%) males. Values of BHIs were increased during treatment at the right MCA (I) 1.18±0.53, (II) 1.26±0.54, (III) 1.37±0.41, with statistical significance between I and III measurement (p<0.05). An increase was noted on the left MCA (I) 1.25±0.53, (II) 1.31±0.55 and (III) 1.32±0.42, but it did not reach statistical significance (p>0.05). Mean MMSE score significantly increased from baseline 27.4±2.3 to 28.5±2.0 after three months of treatment (p<0.001). Functional status showed a statistically significant improvement with mRS score increasing from 2.1±1.0 to 1.1±0.6 (p<0.001). Conclusion - This pilot study showed that 3-month-long oral treatment with vinpocetine 15 mg daily had tendency to increase BHI, indicating improvement of cerebral VMR. It is possible that higher doses of vinpocetine are needed to achieve substantial increase of VMR.]

[INTRODUCTION - Carotid artery stenting as an alternative to carotid endarterectomy is still not accepted by many Hungarian vascular surgeons. The purpose of our study was to prove that carotid artery stenting is effective in the treatment of primary atherosclerotic lesions and it carries a low risk of complications. PATIENTS AND METHODS - 149 patients (86 men, 63 women, 33-82 years old, mean age 57.5 years) were evaluated angiographically. 146 primary atherosclerotic lesions, and 8 post-endarterectomy restenoses were considered for carotid artery stenting. All patients had significant, over 60% stenosis according to NASCET criteria. Atherosclerotic plaques were classified as smooth, irregular and ulcerated. Subtotal occlusions (stenoses over 95%) were noted. The necessity of pre- or postdilation and the types of stent used were registered. Procedural success and periprocedural complication rates were noted. Followup colour Doppler sonography was performed at 1, 6 and 12 months. RESULTS - Subtotal occlusions were detected in 28% of the lesions. Procedural success rate was 149/150 (99%). Stenting was carried out in 86% with Monorail Carotid Wallstent. Predilation or use of protecting device was avoided in 96%. Postdilation was avoided in 6 cases of ulcerated plaques to prevent distal embolisation. Residual stenosis was always less than 30%. Stroke occured in 2.6%, TIA in 0.7%. Two of our patients developed restenosis. CONCLUSION - Carotid artery stenting is a safe alternative to carotid endarterectomy for most patients with primary atherosclerotic stenosis, as it can be carried out with clinical complication rate as low as published in the ACAS.]

[Introduction - Using transcranial Doppler sonography (TCD), changes in blood flow velocity (BFV) can be measured in the Medial Cerebral Artery (MCA) during cognitive effort. Our goal was to define the time-course and laterality of BFV in healthy vo-lunters during arithmetic and verbal fluency tasks according to handedness. Methods - Twelve subjects (8 right-handed, 4 left-handed) were assessed. The TCD registered BFV in both MCA simultaneously. Heart rate was also recorded using TCD. Finally we included a 16-channel EEG. BFV laterality index (LI) was calculated. Participants were asked to count silently and generate words beginning with a specified letter. To estimate hemispheric differences in BFV, two-tailed Wilcoxon tests were utilized along with correlational analyses. Results - During cognitive effort the BFV changed in a triphasic manner in all participants. A 6-8% elevation of BFV was observed in MCAs without latency at the time of the evoking signal. Laterality of BFV developed after 5-13 seconds during cognitive effort in right-, and several seconds later in left-handed subjects. During tasks the BFV increased in the dominant hemis-phere up to 2.6-4.7% compared to the subdominant one. We also calculated the LI. During the verbal task the LI agreed with the handedness in 9 out of 12 subjects. During the mental arithmetic task, agreement was found in 6 out of 12 subjects. According to LI results we found a discrepancy between verbal and arithmetic tests in 3 out of 12 subjects. Conclusion - Cognitive effort elicites significant bilateral BFV increases in the MCAs, which suggests fast neurogenic regulation. The course of BFV during mental arithmetic proved to be different from course BFV assessed during the word fluency task. Based on the laterality of the BFV, the word-generation task was more sensitive in determining the dominant hemisphere when compared to the mental arithmetic task. The use of LI may help to estimate hemispheric functions even in pathologic circumstances.]

[PURPOSE - During the endovascular treatment of internal carotid artery stenosis, one of the most important aspects is reducing of embolic complications. Degree of embolization may be influenced by the force exerted by stent delivery systems and embolic protection devices. We assessed the force emersion produced by various devices on vessel walls and plaques. MATERIAL AND METHOD - Six different commercially available devices were investigated. The force load on vessel wall was measured in a carotid model with vessel angulations of 25, 50 and 75 degree, respectively. The IDTE 2000 CE marked measurement system was used. A transparent, flexible PVC tube was used as a model of the carotid bifurcation, which was 6 mm in width, 1.5 mm wall thickness and 12 mm length. 75-85% stenosis were created in it. The measured data were evaluated and different conclusions were drawn. RESULTS - Forces exerted on vessel walls varied widely among different stent delivery systems. The magnitude of force exertion caused by stent delivery systems significantly exceeded that caused by protecting devices. Protecting devices showed only 30% increase in vessel load at angulation of 75 degrees compared to those at 25-50 degrees. Above 50 degrees of vessel angulation the forces exerted by stent delivery systems considerably increases. CONCLUSIONS - Our results showed that selection of the most proper stent can contribute to decrease in the load of vessel wall. Protecting devices exert significantly lower forces than stent delivery systems, therefore, it seems to be a better choice to advance a protecting device before introducing a stent delivery system. If the vessel angulation exceeds 50 degrees, endarterectomy should be considered, because the vessel wall load will increase radically in that case.]