Clinical Oncology - 2014;1(01)

Clinical Oncology

FEBRUARY 20, 2014

[Management of renal cancer]

MARÁZ Anikó, SZŰCS Miklós

[Targeted anti-cancer agents are used as standard therapies in case of advanced or metastatic clear cell renal carcinoma. Neovascularisation plays an important role in the progression of hypervascularized cancers. Vascular endothelial growth factor (VEGF) is the key molecule in this mechanism. Most of the registered agents inhibit the angiogenesis by blocking the VEGF signalling pathway. It can occur if an antibody binds to the VEGF, so the linkage to the receptor is blocked. This happens in... tovább »

Clinical Oncology

FEBRUARY 20, 2014

[First-line treatment of epithelial ovarian cancer]

RÉVÉSZ János, SZÁNTHÓ András

[The restructuration of Hungarian oncological attendance and medicinal fi nancing resulted in the more intensive participation of clinical oncologists in the therapy of patients with ovarian cancer. The aim of the authors was not to defi ne the taxative therapeutic recommendations, but to give an overview on the development of the therapy and to introduce the deliberation aspects and therapeutic alternatives. While the primary and secondary prevention have developed in case of cervical cancer -... tovább »

Clinical Oncology

FEBRUARY 20, 2014

[Management of pancreatic cancer today]

BODOKY György, LAKATOS Gábor

[Pancreatic cancer (PC) is a major health problem with a poor prognosis. The number of patients with PC is increasing globally. There are no screening tests for early detection of PC, but even when diagnosed early, surgery is possible in only a minority of cases. Managing PC remains a big challenge. For selected patients with borderline or unresectable disease, neoadjuvant therapy offers the potential for tumor downstaging. In patients with resectable disease, adjuvant chemotherapy improves the... tovább »

Clinical Oncology

FEBRUARY 20, 2014

[How long the colorectal cancer should be treated?]

HANS-JOACHIM Schmoll

[Colorectal cancer is one of the leading cancer-related death worldwide. The optimal treatment duration of metastatic colorectal cancer depends on the individual treatment aim and it should be decided by an onco-team and by the patient. In this review several actual issues will be discussed, like the optimal duration of therapy to reach the secondary resection, the accepted response rate and best treatment strategy in case of non-operable colorectal cancer. Furthermore, emphasis is given to the... tovább »

Clinical Oncology

FEBRUARY 20, 2014

[Resistancy and/or progression - Failure or only a short stop]

KOPPER László, SEBESTYÉN Anna

[Nowadays, with the continuously in creasing demand for targeted diagnostics and therapy, we are approaching an ideal stage when the most effective treat ment for a given patient could be selected. However, some basic problems are still waiting to be solved. One major hurdle is the heterogeneity, the formation of subclones with different signifi cance during progression, but with the capacity to overgrow after the failure of the initial therapy. The importance of this phenomenon is refl ected... tovább »

Clinical Oncology

FEBRUARY 20, 2014

[Management of febrile neutropenia in the oncological practice]

SINKÓ János

[Febrile neutropenia is one of the most feared complications of anti-tumor therapy. It can either herald potentially fatal infection or contribute to suboptimal dose-intensity of cancer treatment. Optimal management of affected patients is based upon a multi-disciplinary approach dependent on several factors. Knowledge on institutional epidemiology and predefi ned management strategies improve quality and outcome of anti-infective therapy. In an era of more and more resistant pathogens and... tovább »

Clinical Oncology

FEBRUARY 20, 2014

[Aspiration cytology in tumor diagnostics]

JÁRAY Balázs

[Aspiration cytology (fi ne-needle aspiration, FNA) has increasing role in cancer diagnostics. The review briefl y introduces the relevant methods, their place in the clinical protocolls to identify the given lesions, emphasising advantages and disadvantages. An overview is given on the acceptance of FNA worldwide, and also in Hungary based on private experiences. In certain cases examples are summarized how FNA can contribute to the identifi cation of the diseases, with some important... tovább »