Clinical Neuroscience

[The prognostic relevance of apoptosis in medulloblastoma]

SCHUBERT EO Thomas1, CERVOS-NAVARRO Jorge1

MAY 20, 1996

Clinical Neuroscience - 1996;49(05-06)

[Apoptosis is known to be a phenomenon of prognostic significance in certain neoplasms. Several previous studies have indicated that the prognosis of desmoplastic medulloblastoma is better than that of classical medulloblastoma. We studied 5 desmoplastic and 5 classical medulloblastomas by in situ end labelling of DNA strand breaks to see whether there is any difference in amount or pattern of apoptosis in these subtypes, correlating to the different prognostic behaviour. We found no significant difference neither in amount nor in pattern of apoptosis between the two subtypes. Our results indicate that apoptosis may not be a relevant variable in the prognosis of medulloblastoma.]

AFFILIATIONS

  1. Institute of Neuropathology, Berlin

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