Clinical Neuroscience

[Seven years of neurocare in Csongrád county]


JUNE 01, 1961

Clinical Neuroscience - 1961;14(06)

[We do not know enough about the details of the work of rural mental health institutions, and in the absence of a comprehensive picture, there is no single law to harmonise their operations. In the following, I would like to report on the work of the Csongrád County Neurological Institute for almost seven years and contribute at least to some extent to clarifying the issue. ]


  1. Hódmezővásárhelyi Megyei Ideggondozó Intézet



Further articles in this publication

Clinical Neuroscience

[Corticosteroids and ACTH in neurology ]


[Compile literature data on corticosteroids and ACTH, supplemented by your own experience. It covers those neurological diseases for which good or partial results can be achieved and those for which a definitive opinion has not yet been reached. It lists those conditions in which no therapeutic effect can be expected. Finally, it mentions the neurological complications of steroid therapy. ]

Clinical Neuroscience

[The effects of alcohol on attention, from a forensic and accident psychology perspective]

PAP Zoltán

[ The aim of my study was to draw attention once again to the importance of so-called "mild intoxication" in causing traffic accidents. Based on the latest thinking, I wanted to point out the importance of compulsory blood alcohol testing and the assessment of relative and absolute limits in assessing fitness to drive, from a forensic, mental health and criminal law perspective. Based on the description of a hit-and-run traffic accident, I have attempted to psychologically analyse the mental state of a driver in a state of mild intoxication and to demonstrate that even 1.2% blood alcohol content can, under certain conditions, impair the ability to analyse, it can delay the speed of reaction, prolong the "time of the moment", reduce the number of distinct perceptions, and even, by "emptying the mind", cause a level of unconsciousness so great that the drunk person becomes totally incapable of driving.]

Clinical Neuroscience

[Histamine treatment of psychoses]

KORONKAI Bertalan, ORZÓY Róbert

[From our observations we have seen that the psychopathological target of histamine treatment is mainly affectivitas. In improved cases, a positive evolution of psychic settling preceded the treatment : in most cases, a temporary change in affectivity was observed. Emergence from autism, activation, improved cooperative skills, easier exploration, improvement of psychotherapeutic options are mostly transient results. There was a striking resolution of catatonic inhibition symptoms. With reduced tolerance, a more favourable outcome can be expected. Insulin was found to reduce tolerance, but in two of our cases it did not improve therapeutic options. Histamine treatment may therefore be effective in depressive symptom groups and in akinetic catatonic pictures. Since the results of treatment are generally not durable, its combination with other active treatments has favourable therapeutic potential. ]

Clinical Neuroscience

[Behaviour of the cochleo vestibular artifact in patients with Barré - Lieou syndrome after physiotherapy after combined treatment.]


[Patients with inner ear hearing loss and dizziness had an X-ray examination of the cervical spine. We found positive findings in 12 cases. In addition to vasodilators, these patients were treated with spinal stretching and other physiotherapy. The patients were divided into 3 groups according to whether we found only cervical spondylosis or additionally organic vascular lesions and neurotic symptoms. Patients in the first group, especially those who were treated early, responded well to the complex treatment. In the other groups, the improvement was more modest. Our observation of a small number of cases also supports the association of inner ear disease with cervical spinal column lesions. ]

All articles in the issue

Related contents

Clinical Neuroscience

Cases of inborn errors of metabolism diagnosed in children with autism

CAKAR Emel Nafiye, YILMAZBAS Pınar

Autism spectrum disorder is a neurodevelopmental disorder with a heterogeneous presentation, the etiology of which is not clearly elucidated. In recent years, comorbidity has become more evident with the increase in the frequency of autism and diagnostic possibilities of inborn errors of metabolism. One hundred and seventy-nine patients with diagnosis of autism spectrum disorder who presented to the Pediatric Metabolism outpatient clinic between 01/September/2018-29/February/2020 constituted the study population. The personal information, routine and specific metabolic tests of the patients were analyzed retrospectively. Out of the 3261 patients who presented to our outpatient clinic, 179 (5.48%) were diagnosed with autism spectrum disorder and were included in the study. As a result of specific metabolic examinations performed, 6 (3.3%) patients were diagnosed with inborn errors of metabolism. Two of our patients were diagnosed with classical phenylketonuria, two with classical homocystinuria, one with mucopolysaccharidosis type 3D (Sanfilippo syndrome) and one with 3-methylchrotonyl Co-A carboxylase deficiency. Inborn errors of metabolism may rarely present with autism spectrum disorder symptoms. Careful evaluation of the history, physical examination and additional findings in patients diagnosed with autism spectrum disorder will guide the clinician in the decision-making process and chose the appropriate specific metabolic investigation. An underlying inborn errors of metabolism may be a treatable cause of autism.

Clinical Neuroscience

Comparison of direct costs of percutaneous full-endoscopic interlaminar lumbar discectomy and microdiscectomy: Results from Turkey

ÜNSAL Ünlü Ülkün, ŞENTÜRK Salim

Microdiscectomy (MD) is a stan­dard technique for the surgical treatment of lumbar disc herniation (LDH). Uniportal percutaneous full-endoscopic in­terlaminar lumbar discectomy (PELD) is another surgical op­tion that has become popular owing to reports of shorter hos­pitalization and earlier functional recovery. There are very few articles analyzing the total costs of these two techniques. The purpose of this study was to compare total hospital costs among microdiscectomy (MD) and uniportal percutaneous full-endoscopic interlaminar lumbar discectomy (PELD). Forty patients aged between 22-70 years who underwent PELD or MD with different anesthesia techniques were divided into four groups: (i) PELD-local anesthesia (PELD-Local) (n=10), (ii) PELD-general anesthesia (PELD-General) (n=10), (iii) MD-spinal anesthesia (MD-Spinal) (n=10), (iv) MD-general anesthesia (MD-General) (n=10). Health care costs were defined as the sum of direct costs. Data were then analyzed based on anesthetic modality to produce a direct cost evaluation. Direct costs were compared statistically between MD and PELD groups. The sum of total costs was $1,249.50 in the PELD-Local group, $1,741.50 in the PELD-General group, $2,015.60 in the MD-Spinal group, and $2,348.70 in the MD-General group. The sum of total costs was higher in the MD-Spinal and MD-General groups than in the PELD-Local and PELD-General groups. The costs of surgical operation, surgical equipment, anesthesia (anesthetist’s costs), hospital stay, anesthetic drugs and materials, laboratory wor­kup, nur­sing care, and postoperative me­dication diffe­red significantly among the two main groups (PELD-MD) (p<0.01). This study demonstrated that PELD is less costly than MD.

Clinical Neuroscience

Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias


In aging societies, the morbidity and mortality of dementia is increasing at a significant rate, thereby imposing burden on healthcare, economy and the society as well. Patients’ and caregivers’ quality of life and life expectancy are greatly determined by the early diagnosis and the initiation of available symptomatic treatments. Cholinesterase inhibitors and memantine have been the cornerstones of Alzheimer’s therapy for approximately two decades and over the years, more and more experience has been gained on their use in non-Alzheimer’s dementias too. The aim of our work was to provide a comprehensive summary about the use of cholinesterase inhibitors and memantine for the treatment of Alzheimer’s and non-Alzheimers’s dementias.

Clinical Neuroscience

[The connection between the socioeconomic status and stroke in Budapest]


[The well-known gap bet­ween stroke mortality of Eastern and Western Euro­pean countries may reflect the effect of socioeconomic diffe­rences. Such a gap may be present between neighborhoods of different wealth within one city. We set forth to compare age distribution, incidence, case fatality, mortality, and risk factor profile of stroke patients of the poorest (District 8) and wealthiest (District 12) districts of Budapest. We synthesize the results of our former comparative epidemiological investigations focusing on the association of socioeconomic background and features of stroke in two districts of the capital city of Hungary. The “Budapest District 8–12 project” pointed out the younger age of stroke patients of the poorer district, and established that the prevalence of smoking, alcohol-consumption, and untreated hypertension is also higher in District 8. The “Six Years in Two Districts” project involving 4779 patients with a 10-year follow-up revealed higher incidence, case fatality and mortality of stroke in the less wealthy district. The younger patients of the poorer region show higher risk-factor prevalence, die younger and their fatality grows faster during long-term follow-up. The higher prevalence of risk factors and the higher fatality of the younger age groups in the socioeconomically deprived district reflect the higher vulnerability of the population in District 8. The missing link between poverty and stroke outcome seems to be lifestyle risk-factors and lack of adherence to primary preventive efforts. Public health campaigns on stroke prevention should focus on the young generation of socioeconomi­cally deprived neighborhoods. ]

Clinical Neuroscience

Atypical presentation of late-onset Sandhoff disease: a case report

SALAMON András , SZPISJAK László , ZÁDORI Dénes, LÉNÁRT István, MARÓTI Zoltán, KALMÁR Tibor , BRIERLEY M. H. Charlotte, DEEGAN B. Patrick , KLIVÉNYI Péter

Sandhoff disease is a rare type of hereditary (autosomal recessive) GM2-gangliosidosis, which is caused by mutation of the HEXB gene. Disruption of the β subunit of the hexosaminidase (Hex) enzyme affects the function of both the Hex-A and Hex-B isoforms. The severity and the age of onset of the disease (infantile or classic; juvenile; adult) depends on the residual activity of the enzyme. The late-onset form is characterized by diverse symptomatology, comprising motor neuron disease, ataxia, tremor, dystonia, psychiatric symptoms and neuropathy. A 36-year-old female patient has been presenting progressive, symmetrical lower limb weakness for 9 years. Detailed neurological examination revealed mild symmetrical weakness in the hip flexors without the involvement of other muscle groups. The patellar reflex was decreased on both sides. Laboratory tests showed no relevant alteration and routine electroencephalography and brain MRI were normal. Nerve conduction studies and electromyography revealed alterations corresponding to sensory neuropathy. Muscle biopsy demonstrated signs of mild neurogenic lesion. Her younger brother (32-year-old) was observed with similar symptoms. Detailed genetic study detected a known pathogenic missense mutation and a 15,088 base pair long known pathogenic deletion in the HEXB gene (NM_000521.4:c.1417G>A; NM_000521:c.-376-5836_669+1473del; double heterozygous state). Segregation analysis and hexosaminidase enzyme assay of the family further confirmed the diagnosis of late-onset Sandhoff disease. The purpose of this case report is to draw attention to the significance of late-onset Sandhoff disease amongst disorders presenting with proximal predominant symmetric lower limb muscle weakness in adulthood.