Clinical Neuroscience

[Multiple sclerosis and generalised reticulosarcoma combined case]

PAPP Mátyás1, KIRÁLY Ferenc1

DECEMBER 01, 1961

Clinical Neuroscience - 1961;14(12)

[A 63-year-old patient had multiple sclerosis for about 20 years, which progressed in relapses. 8 months before his death, he developed generalized lymph node enlargement. Autopsy and histopathological examination showed generalized reticulosarcoma throughout the body and diffuse soft tissue and perivascular tumour proliferation in the central nervous system. With minor exceptions, the pia-glia membrane inhibited spread into the neural tissue everywhere except in the corpus pinealea, which may be attributed to the specific biological behaviour of the corpus pinealea in the face of pathological processes. In the central nervous system, in addition to the tumoral proliferation occupying the perivascular spaces, we found multinodular marrow neoplasms, which correspond in their location and histological features to old multiple sclerosis foci. On the basis of the histological picture and the clinical course, the described case must be considered as an accidental encounter of two separate diseases. ]


  1. Budapesti Orvostudományi Egyetem Neurologiai Klinikája és a II. sz. Kórbonctani Intézete



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Clinical Neuroscience

Entwicklung – Reaktion — Prozess

NIKOLA Schipkowensky

In dieser Begriffsbestimmung wird die Untrennbarkeit des somatischen und psy chischen Lebens in den Vordergrund gestellt, was allerdings nicht besagen will, sie seien identisch. Schon dadurch ist aber unterstrichen, dass die Materie das Primäre ist, der Geist — das Sekundäre ; denn Form ohne Inhalt ist undenkbar. Das Bewusstsein, als höchste Form menschlichen Daseins, darf man nicht als ein blosses Epiphänomen seines Organs hinstellen. Die psychische Tätigkeit wird zwar vom Grosshirn geleistet, sie ist aber in ihren Inhalten und in ihrer logischen Gliederung von der objektiven Wirklichkeit deter miniert, deren subjektive Abbildung sie darstellt. Die Definition verweist ferner auf den biologischen Ursprung der menschlichen Persönlichkeit, deren weitere Entwicklung auf der Verbindung von unbedingten Reflexen mit der Er arbeitung kompliziertester dynamischer Stereotypen zeitlicher Verknüpfungen beruht. Schliesslich setzt diese Definition auch die Untrennbarkeit von Psychi atrie und Neurologie voraus : Sie sind einheitliche Glieder der einen medizi nischen Wissenschaft.

Clinical Neuroscience

[On surgical indications for metastases of spinal carcinoma]


[Based on our experience with 40 patients with spinal metastases, we do not refrain from operating on single nodal spinal metastases and paraplegia alone is not a contraindication. The indication for surgery and the expected results depend mainly on the histological and biological characteristics of the primary tumour, the course of the disease and the general physical condition of the patient. Based on the catamnestic evaluation of operated and non-operated patients, surgery can be recommended. Since the severity of compression or paresis is significant in the postoperative outcome, early surgery is desirable. ]

Clinical Neuroscience

[Rare symptom of cervical vertebral chordoma]


[A 60-year-old man with a cervical chordoma, the clinical picture of which was fluctuant and the diagnosis of which could only be clarified by histopathological examination. Contrary to previous literature, reactive marginal sclerosis was detected in vertebra C III, with the chordoma as the primary cause. This case confirms the phenomenon that the clinical picture of vertebral chordoma is atypical and thus difficult to diagnose clinically. ]

Clinical Neuroscience

[Spiractin electroencephalography tests]


[Studies with Spiractin have shown that: 1. in addition to its effect on the respiratory center, it has an excitatory effect on the diffuse activating system of the brainstem. 2. it can be used as a provoking agent in electroencephalography of patients with epilepsy (especially in children). 3. It may also occasionally cause generalized seizures, which should be kept in mind in cases of epilepsy.]

Clinical Neuroscience

[Report on the EEG training course in Marseille ]

WALSO Róbert

[The author reports on the EEG course in Marseille, organized by the International Federation of Societies for EEG and Clin. Neurophysiology" in Marseille from 28 August to 2 September 1961.]

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Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study

NÉMETH Klára Zsófia, SZÛCS Anna , VITRAI József , JUHÁSZ Dóra , NÉMETH Pál János , HOLLÓ András

We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

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Cases of inborn errors of metabolism diagnosed in children with autism

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Clinical Neuroscience

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Clinical Neuroscience

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Clinical Neuroscience

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