Clinical Neuroscience

Clinical perspectives of the new, reversible and selective MAO-A inhibitors


MARCH 20, 1996

Clinical Neuroscience - 1996;49(03-04)

The classical monoamine oxidase inhibitors are used with great care due to their potency to induce severe side effects caused by tyramine interactions from food. With the advent of reversible and selective inhibitors of monoamine oxidase type A their interaction potential was considerably reduced. The first compounds are brofaromine and moclobemide, the latter already, registered for five years in Europe. The paper reviews the essential pharmacological properties of both compounds and gives a survey of the relevant clinical trials. Their efficacy in major depression is established. Regarding therapy resistant depressions, a certain advantage of brofaromine seems to exist. Promising trials in social phobia and panic attacks have been performed with both drugs.


  1. Psychiatric Department, University of Jena
  2. Department of Clinical Pharmacology, University of Göttingen
  3. Psychiatric Department, University of Munich, Germany



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