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Clinical Neuroscience

MAY 30, 2010

[Intracranial propagation of invasive aspergilloma in an immuncompromised patient]

SIMON Márta, VASTAGH Ildikó, VÁRALLYAY György, TURÁNYI Eszter, SRÉTER Lídia, CZIRJÁK Sándor, BERECZKI Dániel

[Aspergillus infection of the central nervous system is a rare disease, occasionally seen among immunocompromised patients. The most frequent pathway is hematogenic dissemination. Less known is the direct propagation from the paranasal sinuses, which is usually observed in immunocompetent patients. We report a patient who developed cavernous sinus syndrome due to an invasive intracranial aspergilloma after longlasting chemo- and steroid therapy for chronic lymphoid leukemia and immunhemolytic anemia. The characteristic features seen on radiological images - brain CT and MRI - suggested the possibility of invasive aspergilloma. Postoperative histology defined the diagnosis. Our case review highlights the importance of considering the possibility of an invasive opportunistic infection of the CNS in an immunocompromised patient presenting a new neurological sign.]