Lege Artis Medicinae

[VALVACE ]

MATOS Lajos

MARCH 21, 2006

Lege Artis Medicinae - 2006;16(03)

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Lege Artis Medicinae

[THE EFFECT OF A BLACK RADISH PREPARATION ON THE REDOX HOMEOSTASIS IN INFLAMMATORY BOWEL DISEASE]

BLÁZOVICS Anna, KOVÁCS Ágota, SZÉKELY Edit, LUGASI Andrea

[INTRODUCTION - Natural antioxidants have been shown to indirectly act on signal transduction pathways and influence the induction of apoptotic genes in several ways. The black radish-based granules contain several bioactive components including isothiocyanates, flavonoids, vitamins and trace elements that can modify various molecular biological pathways. The aim of this study was to find out whether this preparation has an effect on the redox homeostasis of patients with inflammatory bowel disease. PATIENTS AND METHODS - Data from 32 middleaged patients (13 male, 19 female) with moderately active IBD were evaluated. Half of the patients (6 male, 10 female) received 0.2 g/day granules for 6 months in addition to regular treatment. Apart from other routine laboratory measurements, redox parameters including plasma reducing power, H-donor ability, free SH groups and IL-6, IL-1, TNFalpha, bile acids, cholesterol, triglycerides, red blood cell chemiluminescence and HbA1c level were determined. RESULTS - The black radish-based granules had no effect on the activity of inflammatory bowel disease. Beside a positive subjective judgement, bile acid levels had slightly increased and the values of redox parameters had decreased in the plasma by the end of the study period. The granules significantly diminished red blood cell chemiluminescence and moderately reduced the HbA1c-level. CONCLUSION - The results show that the granules rich in antioxidants and isothiocianate have a marked effect on the redox homeostasis of IBD patients even at low doses.]

Lege Artis Medicinae

[CARDIOVASCULAR EFFECTS OF MENOPAUSAL HORMONE REPLACEMENT THERAPY]

PARAGH György, HARANGI Mariann

[The incidence of coronary heart disease in women rises sharply in the years following menopause. Hormone replacement therapy involves the administration of oestrogen, which provides postmenopausal symptom relief and reverses the changes in calcium and lipid metabolism. Moreover, oestrogen is also postulated to engage multiple mechanisms that defend against hypertension. Early observations suggested that postmenopausal women treated with hormone replacement therapy have significantly reduced cardiovascular risk. However, the results of primary and secondary prevention randomized clinical trials confirmed an increased cardiovascular risk rather than a beneficial effect of hormone replacement therapy in highrisk women. Controversy between results of observational and randomized clinical trials may partly be due to the unexplored genetic background. The authors summarize the effects of oestrogen on lipids, inflammation, haemostatic parameters, blood pressure and vascular wall. Genetic factors that modulate the effect of oestrogen as well as current recommendations on hormone replacement therapy after menopause in high risk women are also presented.]

Lege Artis Medicinae

[TREATMENT OF BRONCHIAL ASTHMA]

BÖSZÖRMÉNYI Nagy György

[Although it has no cure, bronchial asthma can be efficiently treated. The use of inhaled corticosteroids and, more recently, long-acting β2- agonist aerosols have produced extraordinary improvement in clinical outcomes, particularly in relation to chronic breathing complaints. Today the aim of pharmacotherapy is to achieve a symptom-free state by the combined administration of long-acting β2-agonist and inhaled corticosteroids in the form of aerosol.]

Lege Artis Medicinae

[Bioterrorism]

dr. NÁDASI Edit, VARJAS Tímea, dr. EMBER István

Lege Artis Medicinae

[The key to satisfaction]

AJKAY Zoltán

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