Lege Artis Medicinae

[Tarnabod – Living on the Edge of Society]

SZALAI László

FEBRUARY 20, 2010

Lege Artis Medicinae - 2010;20(02)

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Lege Artis Medicinae

[Switching from human basal insulin to once daily insulin detemir in type 2 diabetic patients treated by basal-bolus regimen - Results from the LEONCET2, an observational, prospective, multicenter study]

JEMENDY György

[Insulin analogues have been developed in order to overcome some drawbacks of human insulins. Switching from a human insulin-based basal- bolus regimen to once daily detemir could result in improved metabolism and increased safety of the therapy. We assessed the effects of switching from human NPH-insulin to once daily detemir insulin in patients with type 2 diabetes mellitus treated with a basal-bolus insulin regimen. We evaluated the data of 1,474 patients with diabetes (age: 59.1±9.8 years, body weight 89.6±8.6 kg, BMI 31.6±5.4 kg/m2) in an observational, prospective, 24-week, multicenter study. All patients were treated with a basal-bolus regimen consisting of human NPH as basal insulin and a human or analogue insulin as bolus insulin. After enrollment, patients received once daily detemir insulin instead of NPH-insulin, while treatment with bolus insulin was continued. Patients were examined at weeks 12 and 24. By week 24, the mean HbA1c value, irrespective of BMI-categories, decreased significantly (p<0.0001) from 8.63±1.01% by 0.79±0.63%. Fasting blood glucose level decreased from 8.86±1.78 mmol/l to 7.09±1.31 mmol/l; p<0.0001). The target level of HbA1c (<7.0%) was reached by 194 patients (13.1%). The patients’ body weight decreased significantly by week 12 (-0.69±2.00 kg; p<0.0001) and by week 24 (-1.28±2.80 kg; p<0.0001). The changes were more pronounced in higher than in lower BMI-categories (p for trend <0.0001). The mean daily doses of basal insulin were increased from 0.28 IU/kg to 0.33 IU/kg while those of bolus insulins were not changed. The rate of severe hypoglycaemic events decreased significantly (p=0.048) from 2.95 [daytime 1.02, nocturnal 1.93] to 0.06 [daytime 0.04, nocturnal 0.02] episodes/patient-year. In patients with type 2 diabetes mellitus treated with basal-bolus regimen, switching from human basal insulin to once daily insulin detemir results in a significantly improved metabolism, as well as fewer hypoglycaemic events and decreased body weight. Nevertheless, the low rate of patients reaching the glycaemic target implicates that some factors other than an appropriate basal insulin substitution have a role in achieving an optimal metabolic control.]

Lege Artis Medicinae

[Death as a Challenge A Discussion with Criminalist Mihály Filó]

NAGY Zsuzsanna

Lege Artis Medicinae

[Antiplatelet therapy with acetylsalicylic acid - Cardiovascular indications and haemorrhagic complications]

KISS Nóra, KISS Róbert Gábor

[Acetylsalicylic acid effectively blocks the activation of platelets, and becomes a basic element of antithrombotic therapy of patients with high cardiovascular risk. Decrease of platelet reactivity is due to the irreversible inhibition of COX- 1 isoenzime in platelets during treatment. Choosing the right dose is still not an easy task. Bleeding side effects are frequently seen in patients treated with this drug worldwide. Clinical benefit does not improves with escalated doses (300 mg), however the risk of haemorrhagic events increases. Therefore acetylsalicylic acid dose should be reduced to the effective minimal dose (75-150 mg daily) after the acute phase of atherothrombosis in order to prevent side effects. Effect of acetylsalicylic acid differs individually, it might be important screening out those patients who respond less to the drug. Resistance is still an evolving field, proper methodology is to be determined. Right indications of acetylsalicylic acid needs balance between reaching clinical benefit and avoiding side effects. The Hungarian Cardiovascular Therapeutic Consensus Conference 2009 suggested acetylsalicylic acid in primary prevention for those males only, who have overt cardiovascular risk, and SCORE result is more than 10%, with no gastrointestinal haemorrhage in medical history, and with a well-controlled hypertension. Lifelong aspirin prevention should be used after all diagnosed cardiovascular atherothrombotic event as a cornerstone of secondary prevention with low dose (75-150 mg daily) in both genders.]

Lege Artis Medicinae

[Our Monthly Contest – Physicians in Literature]

MEZÔVÁRI Gyula

Lege Artis Medicinae

[Methods of liver support for the treatment of fulminant hepatic failure - therapeutic plasmapheresis, hepatocyte transplantation, methods of biological liver support and new therapeutic approaches: the MARSand the Prometheus treatments]

SCHULLER János

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Evaluation of anxiety, depression and marital relationships in patients with migraine

DEMIR Fıgen Ulku, BOZKURT Oya

Aim - The aim of this study was to evaluate the frequency and characteristics of attacks in patients with migraine, to determine the effects of anxiety or depressive symptoms, and to evaluate the marital relationships of patients with migraine. Method - Thirty patients who were admitted to the neurology outpatient clinic of our hospital between July 2018 and October 2018 and were diagnosed with migraine according to the 2013 International Headache Society (IHS) diagnostic criteria were included in this cross-sectional study. Age, sex, headache frequency and severity, depressive traits, marital satisfaction and anxiety status were examined. We used the Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), Maudsley Marital Questionnaire (MMQ) and Visual Analogue Scale (VAS) for measuring relevant parameters. Results - The mean severity of migraine pain according to VAS scale was 6.93 ± 1.41 and the mean number of migraine attacks was 4.50 ± 4.24. The mean BDI score of the patients was 12.66 ± 8.98, the mean MMQ-M score was 19.80 ± 12.52, the mean MMQ-S score was 13.20 ± 9.53, the mean STAI-state score was 39.93 ± 10.87 and the mean STAI-trait score was 45.73 ± 8.96. No significant correlation was found between age, number of migraine attacks, migraine duration, migraine headache intensity, and BDI, STAI and MMQ scores (p>0.05). But there was a positive correlation between MMQ-S and scores obtained from the BDI and STAI-state scales (p<0.05). Conclusion - In this study more than half of the migraine patients had mild, moderate or severe depression. A positive correlation was found between sexual dissatisfaction and scale scores of depression and anxiety.

Hypertension and nephrology

[The 24th Postgraduate Training Congress of the Hungarian Society of Hypertension]

Journal of Nursing Theory and Practice

[The situation of healthcare vocational training and nurse training at the Ferenczi Sándor Healthcare Vocational School, Miskolc]

KONCZNÉ KISS Krisztina

[Aim of the study: The author aims to examine the opinions of healthcare vocational school students participating in the survey, with regard to further education and working abroad. The study also examines how attractive nursing training is to the students, and whether the student scholarship program has any effect on their choice of major. She attempts to assess the extent to which the place of nursing in the employment hierarchy, and the dimension of prestige, influence the value that society places on nursing. Methodology and sample: The descriptive, prospective research was conducted by means of a questionnaire-based survey of 12-year students prior to taking their general secondary school examinations (n=106), and year 14-15 students in vocational training (n=137), at Ferenczi Sándor Healthcare Vocational School, Miskolc. The data was collated using the SPSS program, and the processing of the results thus obtained took place using statistical mathematical (frequency, correlative coefficient) techniques. Results: Some 58% of the students about to sit their general secondary school examinations would enrol for nurse training at the school if they received a monthly scholarship grant. A total of 83% of the students in vocational training would like to find work that matches their acquired qualification, 63% would like to remain in education, while 35% would like to start work immediately after sitting the examination. More than 80% of the students are attracted by the opportunity to work abroad. In their opinion the social perception of nursing is lower than that of the other occupations. Conclusions: Due to the low prestige of the nursing profession and the low pay, students are not inclined to choose nurse training; however, the system of scholarship grants, as a motivational force, serves as a positive incentive to continue studying. The lack of financial rewards, however, prompts many of them consider migration.]

Lege Artis Medicinae

[Health behavior of tattooed persons]

CZUPY Gábor, PONGÓ Gabriella, MIHÁLFFY Dávid, SUSÁNSZKY Éva

[INTRODUCTION - In post-modern societies tattoo has become decidedly fashionable as acceptance have replaced negative attitudes towards it. We assume that body decoration is a fashion-conscious behavior in the present Hungarian society and thus their lifestyle and risk behavior would not differ from the average of the Hungarian population; also, that there would be no gender differences in the motivations of having a tattoo nor in the messages communicated by tattoos. SAMPLE AND METHOD - Information on tattooed persons was collected on the Internet. The online questionnaire was completed by 508 persons. For processing the data we used the SPSS PC statistical software package. RESULTS - The majority of our sample was under 35 years of age. Respondents have an average of 5-7 tattoos. The most preferred body parts for tattooing are the arms and legs. The primary motivations for having a tattoo are self-expression and the need of commemorating emotions and events. There are significant differences between the characteristics of tattooing of men and women, however, these differences are not related to the social body. The eating habits of men and women are similar; the average number of meals per day is higher than three; the majority of the respondents eats healthy foods and chose their food consciously. They exercise 4-5 hours per week. The proportions of the overweight and the obese are far greater than the nationwide age averages. More than half of the respondents are active smokers. The estimated proportion of heavy drinkers is especially prominent among the tattooed women. SUMMARY - The motivational background and message communication support our assumptions that tattooing is fashion rather than a deviant behavior. The tattooed persons in our sample are health conscious regarding sports and exercise. Appearance has a great importance for them. On the other hand, above average use of legal addictive substances (alcohol) is characteristic among them.]

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