Lege Artis Medicinae

[Predictive value of allergic rhinitis for bronchial asthma in childhood]

BITTERA István1, GYURKOVITS Kálmán1

MAY 29, 1991

Lege Artis Medicinae - 1991;1(09-10)

[Asthmatic manifestations can be expected in 20 to 30% of children with allergic rhinitis. Risk factors were searched to predict later bronchial asthma in time. In a prospective study family history, clinical symptoms and laboratory signs, bronchial hyperreactivity (to histamine and to adenosine) and the lymphocyte beta-adrenergic receptor affinity and number were investigated. 31 of 40 patients responded with bronchoconstriction to histamin and 20 to adenosine. In 16 patients both provocation tests were positive. There was no significant difference in lymphocyte beta-adrenergic receptors between the patient group and the controls. It is suggested that children with allergic rhinitis who show bronchial hyperreactivity and a decreased number or affinity of lymphocyte beta-adrenergic receptors are more at risk to asthmatic manifestations. The risk is higher as the number of receptors decreases with age. The prognostic value of the above mentioned methods will be demonstrated by a subsequent retrospective study.]

AFFILIATIONS

  1. Szent-Györgyi Albert Orvostudományi Egyetem Gyermekgyógyászati Klinika

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