Lege Artis Medicinae

[Molecular morphological methods in laboratory medicine]

BALÁZS Margit, ÁDÁNY Róza

MAY 20, 2001

Lege Artis Medicinae - 2001;11(05)

[Today, the increasing technical arsenal of molecular morphology has not only methodological importance, but also a revolutionary role in diagnostic laboratory medicine. Techniques previously used only in basic research have become widespread in routine diagnostics by now. The development of methodology for detection of genetic alterations has enabled laboratory tests not only to define disease associated pathobiochemical alterations, but also to identify the genetic background of diseases as well. Evolution of these methods caused qualitative changes not only in detection of disease specific alterations, but also in revealing increased individual susceptibility (sometimes at population level) indicating genetic predisposition to the disease. Recently, the classical methodology based on genetic microscopic morphology has been gradually supplemented or even replaced by different in situ hybridization techniques in many laboratories. Using these techniques chromosomal alterations in cells and tissues (including tumor cells) can be detected within one day (or maximum 1-2 days) without in vitro manipulation of cells. These improved techniques allow us to monitor chromosomal changes after the treatment of genetic diseases or define these alterations induced by environmental exposures.]

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RÁCZ István

[According to our knowledge, Helicobacter pylori is a major factor in the pathogenesis of peptic ulcer disease. The prevalence of Helicobacter pylori infection is 70-80% in ulcer patients with the bacteria colonising the mucous surface of the antral mucosa. Eradication therapy against the bacteria leads to complete healing of ulcer disease in about 85-90% of cases. Indications for the eradication and recommended treatment modalities are outlined in several consensus reports; however, in everyday practice a case by case decision is necessary. Present paper summarises two different cases. In the first, the patient has suffered from several relapses of ulcer disease and a successful eradication was performed. Despite of the healing of the ulcer, this patient continued to have prolonged dyspeptic symptoms which called for maintenance antisecretory therapy. The second case is an example that even in a Helicobacter pylori infected patient there could be other reasons for the ulcer pathogenesis. Thorough examinations revealed duodenal manifestation of Crohn’s disease as the background. The message of presented cases is that in each patient individual adaptation of diagnostic and therapeutic algorithms is recommended.]

Lege Artis Medicinae

[MIDAS]

MATOS Lajos

Lege Artis Medicinae

[Case report: gastrointestinal pyogenic granuloma]

SIKE Róbert, SZÉKELY György, DEMETER Pál, SÁPI Zoltán

[In this presentation authors would like to report a case with a lesion related to a ventricularly located pyogenic granuloma. A 65-year-old man was hospitalized with symptoms of acute gastritis. Despite symptomatic treatment for two days he was still in poor condition. Upper panendoscopy revealed Helicobacter pylori associated gastritis and a polypoid lesion with the size of a bean close to the cardia. The histology examination of the lesion verified pyogenic granuloma with gastric localization. After complete Helicobacter pylori eradication followed by PPI and H2 blocker-therapy, the polypoid configuration gradually decreased and after approximately one year it could not be detected and the patient remained symptomfree. According to literature data, pyogenic granuloma is extremely rare in the gastrointestinal tract except for the oral cavity which is the reason why authors intended to call the attention for this rare occurrence.]

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