Lege Artis Medicinae

[IgE monoclonal gammopathy and amyloidosis]

JÁKÓ János1, KASZÁS Ilona1, GESZTESI Tamás1

JUNE 29, 1994

Lege Artis Medicinae - 1994;4(06)

[ IgE myeloma is a very rare disease with only 38 cases reported in the world literature. The authors describe a case of IgE monoclonal gammopathy leading to primary amyloidosis and death in 5 months. This is the first reported IgE monoclonal gammopathy in Hungary. Diagnosis was based on the immunochemical analysis of the concentrated urine. Histologic analysis relevaled amyloidosis. Despite the fact that IgE myeloma is a rare entity, its clinical presentation is highly variable. This case of IgE myeloma presented itself clinically as amyloidosis. Free light chains could be detected from the patient's serum during the entire course of the clinically active disease. In contrast, heavy chains were not detectable, and therefore immunochemical analysis of the concentrated urine is recommended to help in establishing the diagnosis.]

AFFILIATIONS

  1. Haynal Imre Egészségtudományi Egyetem I. Belgyógyászati Klinika Budapest

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