Lege Artis Medicinae



SEPTEMBER 18, 2004

Lege Artis Medicinae - 2004;14(08-09)

[INTRODUCTION - The aim of the study was to obtain epidemiological data on the blood pressure (BP) status of high school students and familiar, constitutional and lifestyle factors influencing their blood pressure. METHODS - After a 10 minutes rest, three repeated BP measurements were taken from the right upper arm, separated by 5 minute intervals. All measurements were obtained by a validated, automated, digital OMRON M4 device. A total sample of 10 194 high school students from Debrecen, included 5163 boys and 5031 girls, whose average age was 16.55±0.99 years. RESULTS - Boys had a significantly higher BP than girls (122.51±13.47/69.58±8.92 mmHg vs. 111.24±12.5/67.41±8.92 mmHg) (p<0.001). There was a positive correlation between weight and BP (rsyst =0.42, rdiast =0.286; p<0.001), height and BP (rsyst =0.326, rdiast =0.145; p<0.001), but not between the age and BP. Subjects whose father had hypertension differed significantly from controls’ BP (p<0.001). If the mother was considered being hypertensive only the diastolic BP differed. Subjects with low birth weight (<2500 grams) in the history had significantly greater systolic (p<0.002), but not diastolic BP than those weighting >2500 grams at birth. Subjects smoking, consuming alcohol, living a stressful life, eating salty foods, or doing regular workout did not differ in terms of both systolic and diastolic BP in our sample. CONCLUSIONS - Significant positive associations were found between BP and height and weight, with a stronger relationship to systolic BP. The males’ BP exceeded the females’ values, while those having hypertension in their family history or low birth weight had also higher BP.]



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BARNA István

[Target blood pressure and reduction in cardiovascular morbidity and mortality have to be accomplished always with the consideration of target organ lesion. Fixed-combination antihypertensive therapy has become accepted based on the recommendations of international and Hungarian medical associations that are aware of the results of evidence based medicine. The fix combinational treatment is more favorable for patients’ compliance. The daily dosage of drugs with 24 hour effect improves the patients’ cooperativeness. During fix combinational treatment higher efficiency, smaller dose and fewer side effects were observed. In combination, the effects of the drugs on blood pressure are additive without any increase in adverse effects. Last, but not least the cost of drugs of fixed combination are lower than buying the drugs separately. After careful consideration the fixed combination therapy can be recommended to the everyday practice.]

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[The diagnosis and therapy of chronic obstructive pulmonary disease - Recommendation of the 2003 consensus conference]


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[The Hungarian Case-Control Surveillance System of Congenital Abnormalities can provide appropriate data for the evaluation of risk and benefits of drugs and pregnancy supplements in pregnant women. Among the main principles, the importance of time factor (the first trimester concept is outdated) and the explanation of frequent false teratogenic findings (e.g. recall bias, chance effect, etc.) are discussed. The main conclusion is that at present the exaggerated teratogenic risk of drugs is much more harmful for the fetus than the rare teratogenic effect of some drugs themselves. Medical doctors and other experts therefore need more education to know the principles and findings of modern human teratology because it may help us to have a better balance between the risks and benefits of drug use during pregnancy. On the other hand, the primary prevention of neural-tube defects and some other congenital abnormalities is demonstrated by periconceptional folic acid or folic acid-containing multivitamin supplementation. Unfortunately, this new method is used rarely and inappropriately (due to the late onset of supplementation) in Hungary.]

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