Lege Artis Medicinae

[A RARE CAUSE OF CYANOSIS - A CASE REPORT ON SULFHEMOGLOBINEMIA]

HARANGI Mariann1, MÁTYUS János1, NAGY Erzsébet2, NAGY Emőke1, PARAGH György1, BALLA József1, OLÁH V. Anna2

JANUARY 21, 2006

Lege Artis Medicinae - 2006;16(01)

[INTRODUCTION - Sulfhemoglobinemia (SHb) is an uncommon cause of cyanosis that is predominantly caused by drugs in adults. CLINICAL CASE - We report on an unusual case of sodium sulfate induced sulfhemoglobinemia in a 61-year-old woman after surgical polypectomy. Fractional hemoglobin derivates were assayed by spectrophotometry and high-performance liquid chromatography (HPLC). The sulfhemoglobinemia ratio was 8.6% in the first sample, and 3.77% a month later measured by spectrophotometry. In the hemolysate a new peak was identified as sulfhemoglobinemia by HPLC. It showed the presence of 9.37% sulfhemoglobinemia in the first sample and 4.88% a month later. After omitting the suspected toxic agent the cyanosis decreased significantly. CONCLUSIONS - The findings underline the importance of routine sulfhemoglobinemia analysis in cases of cyanosis of unknown origin.]

AFFILIATIONS

  1. Debreceni Egyetem Orvos- és Egészségtudományi Centrum, I. Számú Belgyógyászati Klinika
  2. Debreceni Egyetem Orvos- és Egészségtudományi Centrum, Klinikai Biokémiai és Molekuláris Patológiai Intézet

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