Lege Artis Medicinae - 2021;31(08-09)

Lege Artis Medicinae

SEPTEMBER 16, 2021

[Paradigm shift in the drug therapy of HFrEF]

BENCZÚR Béla, HEPP Tamás, VARJAS Norbert

[The incidence and prevalence of heart failure (HF) is constantly increasing, its mor­bidity and mortality are still high, thus the disease burden is huge and its proper treatment is of paramount importance. Subs­tantial evidence on improving its prognosis remains available only by the treatment of chronic heart failure with reduced left ventricular function (HFrEF). There have been published a number of “milestone” studies in the last decades, the results of which fundamentally determined the... tovább »

Lege Artis Medicinae

SEPTEMBER 16, 2021

[Coronavirus disease-2019 among rheumatic musculoskeletal patients – possible outcomes of infection, severe disease development and effectiveness of vaccination]

HODINKA László

[The prevalence of coronavirus infection of patients with inflammatory and rheumatic diseases does not differ significantly from the rate of the disease in the local general population. Patients treated with higher doses of corticosteroids, especially those with more severe systemic autoimmune disease, contract coronavirus infection at a higher rate. The risks of hospitalisation and the mortality rate do not differ significantly from those of the general COVID infected population. Patients... tovább »

Lege Artis Medicinae

SEPTEMBER 16, 2021

[Pulmonary aspects of COVID-19 infection]

BÖCSKEI Renáta Marietta

[COVID-19 caused already the most serious pandemic of the past 100 years with increasing morbidity and mortality rates worldwide. Due to the aerosol-born virus, pneumonia develops in a significant part (ca. 20%) of patients with serious forms of acute respiratory distress syndrome (ARDS) ca. in 5-8% of all cases. For patients with chronic obstructive pulmonary disease, it is very important to save their well-controlled condition and to continue the maintenance therapy in co-morbid COVID-19... tovább »

Lege Artis Medicinae

SEPTEMBER 16, 2021

[Manifestations of COVID-19 in pregnancy]

TÖRÖK Marianna, VEZÉR Márton, ZUBEK László, KESZTHELYI Márton, VÁRBÍRÓ Szabolcs

[There are confirmed COVID-19 infections in Hungary since March 2020. This disease caused by SARS-CoV-2 was initially known not to impose special risk on pregnant women, but probably due to the increasing number of cases and the latest mutations, this is no longer true nowadays. Recent outcomes suggest that pregnancy increases the risk of hospital admission, invasive ventilation and death with higher odds of preterm birth and caesarean sec­tion. Seemingly, vertical infection occurs only in a... tovább »

Lege Artis Medicinae

SEPTEMBER 16, 2021

[Psychiatric conditions not only influence the severity of clinical outcome of COVID-19 but also the medication of mental diseases]

VONYIK Gabriella, SZÉKÁCS Béla, NADUBINSZKY Gábor

[The disease process in psychiatric patients who contracted SARS-CoV-2 infection might become more severe because of their impaired general health, comorbidities and unhealthy lifestyle. However, among all psychiatric conditions statistically significant correlation with severe and lethal outcome have been found only in schizophrenia with possible association of multiple immune dysfunctions. While the antipsychotic clozapine used in treatment resistant schizophrenia seems to decrease the... tovább »

Lege Artis Medicinae

SEPTEMBER 16, 2021

[Bradykinin-cytokin-storm and its pathomechanism in very severe Covid-19]

SZÉKÁCS Béla, KÉKES Ede, VÁRBÍRÓ Szabolcs, DEBRECZENI Lóránd

[The authors review the pathomechanism of severe COVID-19 leading to systemic uncontrollable inflammation, thrombotic events and other complications. The review includes the extremely complex interactions between the infecting coronavirus and the in loco cellular-tissue contact system, the kinin-kallikrein and the renin-angiotensin systems. Authors critically evaluate some potential therapeutic interventions aiming at the mitigation of the dominant bradykinin-cytokine storm in the background of... tovább »

Lege Artis Medicinae

SEPTEMBER 16, 2021

[RAAS inhibitors therapy – COVID-19 pandemic]

KÉKES Ede

[Acute respiratory syndrome with various signs and outcomes caused by the SARS-CoV-2 virus is the biggest challenge facing health systems worldwide today. The renin-angiotensin-aldosterone and kinin-kallikrein systems and within these two endopeptidases (ACE and ACE2) play a crucial role in the developing clinical feature of COVID-19. Adverse effects of the ACE-stimulated Ang II/AT1R axis (oxidant, pro-inflammatory effect, vasoconstriction) are counterbalanced by the ACE2-induced AT2R and MasR... tovább »

Lege Artis Medicinae

SEPTEMBER 16, 2021

[Possible ophthalmological symptoms and complications of COVID-19 infections]

NAGY Zoltán Zsolt

[The COVID-19 infection that started in December 2019 in China became a pandemic. Initially, the publications were dealing with respiratory symptoms, but later on other non-specific, pandemic related syndromes were discussed in the medical literature, among them more and more ophthalmological symptoms. Essential ophthalmological knowledge is important since the air-born droplet infection is invading generally the mucous membranes. Conjunctiva is the most important mucous membrane of the eyes.... tovább »