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[The hormone-like effects of vitamin D and its mechanism of action were extensively investigated during the last decade. The key to these effects lies in the receptor, in the interaction of the D hormone/receptor complex and in the regulator effects of vitamin D/receptor complex on other genes. The details of the vitamin D receptor structure became known during the last years. This new data shed light on a number of new aspects of vitamin D action, of which some have already gained clinical significance. Present review attempts to summarize the most recent data available in this field.]
[Regional lymphadenectomy (or lymph node dissection) is the integral part of the surgical treatment for most solid malignant tumors. The purpose of this procedure is twofold: firstly, to achieve locoregional control of the disease and secondly, the staging of the disease. The subsequent complication and morbidity rate of regional lymphadenectomy can be significant: the tumor can disseminate after surgery in a number of patients conventionally staged as node negative (pN0). In the 90’s, a new and minimally invasive surgical regional staging method, the sentinel lymph node biopsy has been developed and introduced into clinical practice. Based on the theory of the sentinel lymph node concept, the lymphatic drainage of the tumor is mapped, and the first tumor-draining lymph node, the sentinel lymph node is localized and removed. The detailed histological examination of this lymph node determines the regional tumor status more sensitively than routinely used staging methods and is more cost effective. This technique may allow the use of selective surgical or radiation treatment of tumors draining to superficial lymph node basins. The history and theoretical background of sentinel lymph node biopsy are also reviewed with the feasibility, technique and role of this new method in different tumor locations discussed.]
1.
Clinical Neuroscience
[Headache registry in Szeged: Experiences regarding to migraine patients]2.
Clinical Neuroscience
[The new target population of stroke awareness campaign: Kindergarten students ]3.
Clinical Neuroscience
Is there any difference in mortality rates of atrial fibrillation detected before or after ischemic stroke?4.
Clinical Neuroscience
Factors influencing the level of stigma in Parkinson’s disease in western Turkey5.
Clinical Neuroscience
[The effects of demographic and clinical factors on the severity of poststroke aphasia]1.
2.
Clinical Oncology
[Pancreatic cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up]3.
Clinical Oncology
[Pharmacovigilance landscape – Lessons from the past and opportunities for future]4.
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