LAM KID

[New findings in the cortical bone biology and its role in bone fractures]

BALOGH Ádám1, BHATTOA Harjit Pál2

JULY 20, 2011

LAM KID - 2011;1(01)

[The authors surveyed the already known factors responsible for the osteoporotic bone fragility. Then the results of using modern imaging techniques (micro-CT, high-resolution peripheral computed quantitative tomograph - HR-pQCT) and advanced computer analytic methods (finite element analysis, FEA) are presented. These data - beyond the already known fracture risk factors (age, risk of falling, bone mineral density - BMD, and fine structure damage of trabecular bone) are stressing the importance of the (micro)damage of cortical bone as a fracture risk factor, which has been still underrated. The cortical thickening and increased porosity - verified on various population samples - are increasing the risk of fractures in certain subgroups of subjects having identical BMD values, even among those, who are considered only osteopenic by the earlier classification based on BMD values. Backed with modern software batteries, the new imaging techniques are expected to enter clinical application in the near future. Pharmacologic agents with stronger cortical effect are already available and research is continuing to find new drugs to use in the management of osteoporotic patients of high fracture risk.]

AFFILIATIONS

  1. Debreceni Egyetem, Általános Orvosi Kar, Orvos- és Egészségtudományi Centrum, Szülészeti és Nôgyógyászati Klinika
  2. Debreceni Egyetem, Általános Orvosi Kar, Orvos- és Egészségtudományi Centrum, Klinikai Biokémiai és Molekuláris Patológiai Intézet

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