LAM Extra for General Practicioners

[ORAL CARCINOMA AND ITS PREBLASTOMATOSES: THE ROLE OF PAPILLOMAVIRUS INFECTION AND THE PROSPECTS OF EARLY DIAGNOSIS]

DECSI Gábor, TARNAI Zsófia, ZSEDÉNYI Ádám, BUZÁS Krisztina, NAGY Katalin, SONKODI István, MINÁROVITS János

APRIL 20, 2014

LAM Extra for General Practicioners - 2014;6(02)

[The high incidence of oral carcinoma in Hungary is attributed primarily to tobacco and alcohol use. Recently, however, a series of publications suggested a role for humán papillomavirus in the development of oral carcinoma. For this reason we reviewed the literature regarding the associations of human papillomavirus with oral carcinoma and its preblastomatoses. We also overviewed research aiming to develop reliable methods for early diagnosis that are also suitable for screening. Early diagnosis and treatment may significantly improve the prospects of the patient. In addition, the addition of already available human papilloma virus vaccines into national vaccination programs and the extension of vaccination for both sexes may decrease the prevalence of oral carcinoma associated with human papillomavirus infection that primarily affects younger populations.]

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LAM Extra for General Practicioners

[DOES THE VITAMIN K2 PLAY A ROLE IN THE PREVENTION OR TREATMENT OF OSTEOPOROSIS? - A SYSTEMATIC REVIEW]

SZILI Balázs, TAKÁCS István

[The physiological role of vitamin K in blood clotting and bone metabolism is well known. A number of articles have been published recently about the effects of vitamin K2 on bone. Non-professional media promotes vitamin K2 as a potent tool for the prevention and treatment of osteoporosis. Nevertheless vitamin K2 is not included in either Hungarian, or European, or Ameri - can guidelines as an anti-osteoporotic me - dication. Our aim was to review the literature and provide a systematic review on the role of vitamin K2 in the prevention and treatment of osteoporosis. We have searched articles on http://pubmed. org available on 14. February 2014. Our search terms were: („ vitamin K2” OR „ menaquinon” OR „ MK-7” OR „ menantrenon”) AND „ osteoporosis”. We have only reviewed original articles that discussed the relationship of vitamin K2 and osteoporosis, and had at least the abstract available in English. Of the 155 articles found, 135 had a relevant topic, 126 had at least the abstract in English. Of these, 73 were original articles, including 44 human studies (8 doubleblind, controlled, 26 open-label, controlled, 5 observational and 5 cross-sectional studies) and 29 animal or in vitro models. In the non-Asian population there is no evidence for fracture-preventing or BMD-increasing effect of vitamin K2 treatment. The currently recommended anti-osteoporotic medications are significantly more efficient compared with the BMD increase observed in some Asian studies.]

LAM Extra for General Practicioners

[MEET THE NEW MEMBER OF THE ALPRAZOLAM FAMILY]

FERENCZ Csaba

[The struggle against anxiety disorders and symptoms of anxiety is as old as the history of human healing. The development of anxiolytics has constituted an important field of pharmacology from the very beginning. The appearance of benzodiazepines and high-potential benzodiazepines, developed as a later evolution of the former compounds, is considered a milestone in this battle. Today alprazolam is their most widely-used representative that can be considered a golden standard. Besides its agent, the formulation of the drug is also significant, as it helps in the administration, absorption and bioavailability of the agent and even for the establishment of good compliance. Nowadays we can witness the development of medicine families containing the same active ingredient and consisting of various products. In the case of alprazolam, we can welcome a new member of the family following the immediate-release tablets and the extended-release tablets. The aim of this paper is the introduction of the new member of the alprazolam family: the sublingual tablet.]

LAM Extra for General Practicioners

[ANALYSIS OF THE KNOWLEDGE ON CERVICAL CANCER AND ATTENDANCE INDICATORS OF CERVICAL SCREENING]

VAJDA Réka, KARAMÁNNÉ Pakai Annamária, ÉLIÁS Zsuzsanna, SÉLLEYNÉ Gyuró Mónika, TAMÁS Péter, VÁRNAGY Ákos, KÍVÉS Zsuzsanna

[OBJECTIVE - The study aims to explore knowledge on cervical cancer and cervical screening among women with 9-14 yearold daughters, and learning the attitudes towards screening, the motivation of attendance at or absence from screening. DATA AND METHODS - A quantitative, cross-sectional study was conducted using our own questionnaire in the town Nagyatád in 2012. Study participants included women who had 9-14 year-old daughters and a registered home address in Nagyatád. We received valid responses from 186 people (response rate: 75.3%). RESULTS - The interviewed women’s knowledge on cervical cancer differed significantly depending on their age, education, marital status, and economic activity. Only 45 women with higher education (p=0.043) were considered to be well informed on the subject. However, their willingness to participate in cancer screening was more favorable than their knowledge, 96.2% of the women claimed to attend an annual cancer screening. The average age of respondents was 20.92 years at first visit. CONCLUSIONS - Although the participation rate was much higher compared with that in previously published studies, it is of great importance to increase the mothers’ knowledge on cervical cancer and the factors that promote its development, so that they can pass their knowledge to their children and strengthen their protection against one of the most common sexually transmitted viral infection and the development of cervical cancer.]

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[Worldwide, cervical cancer remains the second most frequent malignancy. The estimated number of new cases is 450,000 per year. Approximately 80% of affected women live in developing countries where access to cervical screening programmes is limited. In Europe, more than 12,800 women die each year from this preventable disease. Human papilloma virus (HPV) infection has been proved to be a potential cause of cervical cancer. Secondary screening decreases the morbidity and mortality of the disease, but does not prevent HPV infection. HPV-DNA can be detected in 90-100% of preinvasive and invasive cervical cancer cases. Trials assessing prophylactic anti-HPV vaccination have confirmed that the vaccination is a suitable method for the primary prevention of precancer lesions and cervical cancer.]

LAM Extra for General Practicioners

[THE RELATIONSHIP BETWEEN HUMAN PAPILLOMA VIRUS AND CERVICAL CANCER]

KOISS Róbert, SIKLÓS Pál

[Worldwide, cervical cancer remains the second most frequent malignancy. The estimated number of new cases is 450,000 per year. Approximately 80% of affected women live in developing countries where access to cervical screening programmes is limited. In Europe, more than 12,800 women die each year from this preventable disease. Human papilloma virus (HPV) infection has been proved to be a potential cause of cervical cancer. Secondary screening decreases the morbidity and mortality of the disease, but does not prevent HPV infection. HPV-DNA can be detected in 90-100% of preinvasive and invasive cervical cancer cases. Trials assessing prophylactic anti-HPV vaccination have confirmed that the vaccination is a suitable method for the primary prevention of precancer lesions and cervical cancer.]

Lege Artis Medicinae

[Oral carcinoma and its preblastomatoses: the role of papillomavirus infection and the prospects of early diagnosis]

DECSI Gábor, TARNAI Zsófia, ZSEDÉNYI Ádám, BUZÁS Krisztina, NAGY Katalin, SONKODI István, MINÁROVITS János

[The high incidence of oral carcinoma in Hungary is attributed primarily to tobacco and alcohol use. Recently, however, a series of publications suggested a role for humán papillomavirus in the development of oral carcinoma. For this reason we reviewed the literature regarding the associations of human papillomavirus with oral carcinoma and its preblastomatoses. We also overviewed research aiming to develop reliable methods for early diagnosis that are also suitable for screening. Early diagnosis and treatment may significantly improve the prospects of the patient. In addition, the addition of already available human papilloma virus vaccines into national vaccination programs and the extension of vaccination for both sexes may decrease the prevalence of oral carcinoma associated with human papillomavirus infection that primarily affects younger populations.]