Hypertension and nephrology

[The importance of epithelial-mesenchymal transition in kidney fibrosis]

NAGY SZAKÁL Dorottya1, SZEBENI Beáta2, SZIKSZ Erna2, HIMER Leonóra2, REUSZ György1, VÁSÁRHELYI Barna2, TULASSAY Tivadar1,2, VANNAY Ádám2

FEBRUARY 28, 2011

Hypertension and nephrology - 2011;15(01)

[Epithelial-mesenchymal transition (EMT) plays a central role in physiological and pathological processes of embryogenesis, carcinogenesis and tissue fibrosis. During EMT epithelial cells may transform to myofibroblasts, which are the effector cells of fibrosis. In our summary the process of EMT and its medical importance will be reviewed in relation to renal fibrosis. Regardless of the initiating cause the final common mechanism of organ fibrosis is similar in the different chronic renal diseases. It always involves major inflammatory responses, however the molecular mechanisms involved are still elusive. The EMT now takes centre stage as the point of convergence between inflammation and the progression of degenerative fibrotic diseases. Understanding the pathomechanism of EMT and the significance of signalling pathways involved in this process may lead to a new therapeutic approach in the treatment of chronic renal diseases.]

AFFILIATIONS

  1. Semmelweis Egyetem, Általános Orvostudományi Kar, I. Sz. Gyermekgyógyászati Klinika, Budapest
  2. Magyar Tudományos Akadémia, Semmelweis Egyetem, Gyermekgyógyászati és Nephrológiai Kutatócsoport, Budapest

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