Hypertension and nephrology

[Effect of angiotensin-converting enzyme gene insertion/deletion polymorphism on survival of hemodialyzed patients]

KISS István1,2,3, SZEGEDI János4, KULCSÁR Imre5, AMBRUS Csaba1,2,3, KERKOVITS Lóránt2, TISLÉR András6, KISS József Zoltán7

SEPTEMBER 20, 2015

Hypertension and nephrology - 2015;19(04)

[Introduction: There are inconsistent observations regarding the earlier studies of the connection between ACE gene I/D polymorphism and the cardiovascular mortality. In the case of hemodialyzed patients suffering from chronic kidney disease the DD polymorphism connected to the elevated ACE levels was pointed out to be connected to the mortality rate primarily in patients with diabetes. The previous observations were verified by us during the analyzation of the short-term (three year period) survival data. We hypothesized that the significance of the ACE gene I / D polymorphism in chronic kidney disease would be verified and that during long-term observations (10 year period) the previous results could be validated. Method: In our non-invasive, prospective and multicentre study clinical data was collected from 746 patients whose blood samples were genotyped for ACE gene I/D single nucleotide polymorphism. Three genotype groups (I/I, I/D és D/D) were created during the analyzation of the mortality that was done using multivariate Cox proportional hazard models. Results: The mean age of the HD patients was 54.9 years, 46,8% of all patients were female. The prevalence of diabetes was 19.3%. ACE inhibitor therapy was prescribed for 47.9% of all patients. The median duration of dialysis before the start of the study was 23.8 months (IQR 11.2-47.1). The most frequent genotype was I/D (42.6%), followed by D/D (37.7%) and I/I (19.7%) genotypes. During the ten year follow- up of patients, the median follow-up was 29.8 months (IQR 12.6-63.4). The D/D genotypes showed lower survivability (I/I vs. D/D: log-rank test: p=0.04) from the group of patients without ACE inhibitor therapy. In multivarite Cox regression models D/D genotype compared with I/I genotype only showed that it significantly determines mortality in patients with no ACE inhibitor therapy (HR 0.67, 95% CI 0.46-0.97, p=0.03). Conclusions: There was no difference in survival among unselected patients with different genotypes. Our data suggests that hemodialyzed patients with the D/D genotype might have inferior outcome, and ACE inhibitor therapy may be associated with improved survival in this subgroup.]

AFFILIATIONS

  1. B.Braun Avitum 1.Sz Dialízisközpont, Budapest
  2. Szent Imre Egyetemi Oktató Kórház, Nephrologia-Hypertonia Profil és Aktív Geriátriai Részleg, Budapest
  3. Semmelweis Egyetem, Általános Orvostudományi Kar, II. Sz. Belgyógyászati Klinika, Geriátriai Tanszéki Csoport, Budapest
  4. B.Braun Avitum Dialízis Hálózat, 2. Sz. Dialízisközpont, Nyíregyháza
  5. B.Braun Avitum Dialízis Hálózat, 6. Sz. Dialízisközpont, Szombathely
  6. Semmelweis Egyetem, Általános Orvostudományi Kar, I. Sz. Belgyógyászati Klinika, Budapest
  7. Aesculap Akadémia Doktorjelöltek Iskolája, Budapest

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