[Notwithstanding the abundance of pharmacotherapeutic options available, the rate of optimal blood pressure control may be estimated as low as 20 to 40 per cent throughout Europe. The underlying causes of this include, among others, the substantial impact of using free combinations of several antihypertensive - this practice results in rather poor patient adherence. Fixed-dose dual combinations have been introduced just about two decades ago, and their popularity has been increasing progressively since then. Nevertheless, in a considerable proportion (>30%) of patients, achieving optimal blood pressure control requires treatment with at least three antihypertensive acting on different targets. Accordingly, a rational demand has grown for triple-fixed combinations. In Hungary, the fixed combination of perindopril (an ACEI), indapamide (a thiazide-like diuretic), and amlodipine (a calcium channel-blocker) has been available since last year. Our experience with this product shows, as confirmed by ABPM studies, that its routine use in hypertensive patients with cardiological comorbidities improves patient compliance, thereby enhancing also long-term blood pressure control.]

[The incidence and prevalence of ischaemic and haemorrhagic stroke declined continuously from 1970 to 2010. The rate of incidence was the lowest in North America, within Europe in the Mediterranean countries, France and in Asian developed countries. The incidence and prevalence the progress of age have in - creased respectively. The outcome of haemorrhagic stroke is worse everywhere, than that of ischaemic form, rate of mortality/incidence is greater.]

[Managing the fluid balance in patients with chronic heart and kidney disease is critical, it exceptionally affects the success of the therapy. Therefore, it is crucial to recognize and treat the fluid overload or depletion as soon as possible. Plenty of methods are available to assess fluid status, which can help us to find the right diagnosis, plan and follow the therapy of the patients. The aim of our review article is to present the current techniques of estimating fluid status. Beside the widely used methods (e.g. physical examination, laboratory testing) we describe other techniques which are less common in the Hungarian clinical practice but easy to use, such as chest sonography and bioimpedance spectroscopy. To choose the right approach for assessing fluid status, we have to examine the advantages and disadvantages of the methods in consideration of the patient’s individual needs.]