Hungarian Immunology

[PAPER REVIEW]

VÁNCSA Andrea

MARCH 20, 2009

Hungarian Immunology - 2009;8(01)

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Hungarian Immunology

[DROP2 - Interdisciplinary forum among rheumatologists, gastroenterologists, hematologists and oncologists Scientific program]

Hungarian Immunology

[Diagnosis and treatment of the Raynaud-syndrome]

CSIKI Zoltán

Hungarian Immunology

[FORTHCOMING CONFERENCES]

Hungarian Immunology

[Features of serum carnitine ester profile in systemic sclerosis]

TALIÁN Csaba Gábor, KISS György Csaba, MELEGH Béla, CZIRJÁK László

[AIMS - Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular abnormalities, fibrosis, inflammatory changes, and late stage atrophy with obliterative vasculopathy. Clinically it has two distinct subtypes, limited (lcSSc) and diffuse cutaneous systemic sclerosis (dcSSc). Carnitine is an essential metabolite with ester forming capability. We investigated the possible relationship between carnitine metabolism and systemic sclerosis, stratified by disease subgroups. PATIENTS AND METHODS - We performed comparative measurements of carnitine profile in 107 systemic sclerosis patients (78 lcSSc and 29 dcSSc) and 47 healthy controls using triple quadrupol ESI mass spectrometry. RESULTS - C2-, C3-, C8-, C10:1- and C10-carnitine ester levels were moderately decreased in the serum of the patients, while C5- and C6-carnitine ester concentrations increased in both types of the disease compared with controls; as a summary, these changes altogether led to reduced total carnitine ester concentrations. Free carnitine level remained unaffected. CONCLUSIONS - These results show that both types of SSc have a moderate influence on shortand medium chain carnitine ester metabolism, but likely do not affect the quantity of the free carnitine reserves.]

Hungarian Immunology

[Károly Rauss, the immunologist]

RALOVICH Béla

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USLU Ilgen Ferda, ELIF Gökçal, GÜRSOY Esra Azize, KOLUKISA Mehmet, YILDIZ Babacan Gulsen

We aimed to analyze the clinical, laboratory and neuroimaging findings in patients with sporadic Creutzfeldt-Jakob disease (CJD) in a single center as well as to review other published cases in Turkey. Between January 1st, 2014 and June 31st, 2017, all CJD cases were evaluated based on clinical findings, differential diagnosis, the previous misdiagnosis, electroencephalography (EEG), cerebrospinal fluid and cranial magnetic resonance imaging (MRI) findings in our center. All published cases in Turkey between 2005-2018 were also reviewed. In a total of 13 patients, progressive cognitive decline was the most common presenting symptom. Two patients had a diagnosis of Heidenhain variant, 1 patient had a diagnosis of Oppenheimer-Brownell variant. Seven patients (53.3%) had been misdiagnosed with depression, vascular dementia, normal pressure hydrocephalus or encephalitis. Eleven patients (87%) had typical MRI findings but only 5 of these were present at baseline. Asymmetrical high signal abnormalities on MRI were observed in 4 patients. Five patients (45.4%) had periodic spike wave complexes on EEG, all appeared during the follow-up. There were 74 published cases in Turkey bet­ween 2005 and 2018, with various clinical presentations. CJD has a variety of clinical features in our patient series as well as in cases reported in Turkey. Although progressive cognitive decline is the most common presenting symptom, unusual manifestations in early stages of the disease might cause misdiagnosis. Variant forms should be kept in mind in patients with isolated visual or cerebellar symptoms. MRI and EEG should be repeated during follow-up period if the clinical suspicion still exists.

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[Introduction - Stroke is the third leading cause of death worldwide (following cardiovascular and cancer mortality) and associated with serious disability for the vast majority of patients. There is no salvage therapy for irreversibly damaged brain areas, improving the circulation of the surrounding hypoperfused territories may be associated with benefitial clinical states. Cerebral hypoperfusion may play a role in the pathogenesis of other kind of neurological diseases, improvement of global circulation may have a preventive effect on these conditions. Aims - The aim of our study was to review the experimental and clinical articles focusing on the role of vinpocetin in different neurological conditions. Results - Vinpocetin appears to have several different mechanisms of action that allow for its antiinflammatory, antioxidant, vasodilating, antiepileptic and neuroprotective activities in experimental conditions. On the other hand, several meta-analysis of the existing studies in acute stroke examining short and long term fatality rates with vinpocetin was unable to assess efficacy. In chronic cerebrovascular patients, vinpocetin improves impaired hemorheological variables, has significant vasodilating properties, improves endothelial dysfunction, neuroimaging studies showed selective increase in cerebral blood flow and cerebral metabolic rate, all of which are potentially beneficial in cerebrovascular disease and may improve cognitive functions. Summary - Based on the above mentioned results vinpocetin plays an important role both in basic research and in clinical management of different neurological diseases.]