Hungarian Immunology

[Multiple interactions between heat shock proteins and innate immunity]

PROHÁSZKA Zoltán, FÜST György

AUGUST 20, 2003

Hungarian Immunology - 2003;2(04)

[Heat-shock proteins play essential roles in all living cells and their structure is highly conserved during evolution. Their expression is up-regulated in response to diverse stress stimuli and HSPs may function as a marker of danger. There are multiple processes in innate immunity to recognize HSP. Due to their strong recognition and conserved nature HSPs are immunodominant antigens in most of the bacterial infections and are therefore frequently key players in infection induced autoimmunity. The antigenic picture of HSPs is coded in the immunological homunculus in mammalian organisms and the maintenance of regulating autoimmunity protects against self-damaging processes.]

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