Clinical Oncology - 2020;7(3)

Clinical Oncology

AUGUST 28, 2020

[The hormonal therapy of breast cancer]

VÉGH Éva

[Breast cancer will be diagnosed in 12% of women in well-developed countries over the course of their lifetimes. This review focus on current approaches and strategies of systemic endocrine therapy of breast cancer. Breast cancer can be divided into three main subgroups based on the presence and absence of molecular markers (ER, PR, HER2 receptors). For patients without metastases the therapeutic goals are preventing the locoregional and distant recurrence. The length of adjuvant hormonal... tovább »

Clinical Oncology

AUGUST 28, 2020

[Complex treatment of head and neck cancers – overview]

DÁNOS Kornél, TAMÁS László

[Treatment of head and neck squamous cell carcinomas (HNSCC) is exceptionally complex, requiring the close cooperation of the head and neck surgeon, radiation oncologist and medical oncologist. Excellent tumor control should be our primary goal, however, the selection of treatment should not only be guided by oncologic radicality but by the need of satisfactory quality of life (as most local therapies affect respiratory, swallowing and/or speech function), too. Based on the appropriate... tovább »

Clinical Oncology

AUGUST 28, 2020

[ESMO Clinical Research Observatory (ECRO). Improving the effi ciency of clinical research through rationalisation of bureaucracy]

PEREZ-GRACIA Luis Jose, AWADA Ahmad, CALVO Emiliano, AMARAL Teresa, ARKENAU Hendrik-Tobias, VIKTOR Gruenwald, BODOKY Gyorgy, LOLKEMA P Martijn, NICOLA Di Massimo, PENEL Nicolas, VERA Ruth, SANMAMED F Miguel, DOUILLARD Jean-Yves

Clinical Oncology

AUGUST 28, 2020

[Importance of hypoxia in tumor progression: road to Nobel price and novel therapeutic opportunities]

KOPPER László, SEBESTYÉN Anna, TÍMÁR József

[It is now evident that cancer hypoxia is one of the new hallmark of cancer due to its consequences in gene expression, metabolism and biology. The importance of cancer hypoxia was recognized by the Nobel-price award in 2019. There are three major causes of cancer hypoxia: insuffi cient vascularization, systemic hypoxia of the host and constitutive activation of oncogene driven signaling pathways, all leading to a unique form of genetic reprogramming by HIF transcription factors. The... tovább »

Clinical Oncology

AUGUST 28, 2020

[The use of vitamins and trace elements in oncology]

RÉPÁSI Eszter

[The effects of diet on development cancer and tumor control has been studied for along time, because diet has a key role in treatment of cancer. A multidisciplinary team is needed for proper use of vitamins and trace elements in cancer patients. This multidisciplinary team (oncologist, dietitian, laboratory assistant) can provide the professional supervision from the medical examination to the practical implementation, which can control the proper intake of these nutrients and the individual... tovább »

Clinical Oncology

AUGUST 28, 2020

[The indication for surgical resection in secondary liver malignancies - New therapeutic approaches]

LUKOVICH Péter, PŐCZE Balázs

[During the last decade liver surgery underwent major improvement: mortality rates reduced meanwhile new surgical approaches converted surgeons’ consideration on many advanced cases likely to be resectable. Liver is the most frequent site for tumor metastases and liver metastasis surgery experienced major changes as well. As long as liver resection related mortality rates have decreased indication for operative treatment of liver metastasis with certain primary tumors (stomach, pancreas) gained... tovább »