Clinical Neuroscience

The treatment of cluster headache

KARL Ekbom1

JANUARY 20, 1994

Clinical Neuroscience - 1994;47(01-02)

Cluster headache attacks occur in series, lasting for weeks or months, that are separated by remission periods. However, in less than 15 %, patients suffer from a chronic syndrome, that is regular attacks for one year or longer. The spontaneous course of cluster headache may cause some problems when evaluating clinical trials. For instance, it may be difficult to decide whether an observed improvement is due to effects of the trial drug or to a spontaneous remission. Most studies published hitherto have used an open treatment app- roach – using a concomitant treatment – which is understandable, because the placebo effect has been regarded as being small in cluster headache. In fact, there are in the previous literature only few well-designed, randomised, double-blind clinical trials.

AFFILIATIONS

  1. Department of Neurology, Söder Hospital, S-118 83 Stockholm, Sweden

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