Clinical Neuroscience

[The fate of the pituitary graft in the human body]

GÁTAI György1

DECEMBER 22, 1950

Clinical Neuroscience - 1950;3(04)

[In calf hypophyses transplanted into human thymus, progressive necrosis was observed at 7 weeks and complete necrosis at 13 weeks. The necrosis is centrifugal, most pronounced in the central parts of the graftatum. The connective tissue sheath of the pituitary plays a major role in the death of the transplanted material, with the sheathless parts dying the latest. Transplants have only a temporary and partial effect and in the case of serial transplants the effect of surgery is reduced.]

AFFILIATIONS

  1. Budapesti Eötvös Lóránd Tudományegyetemi Elme- és Idegkórtani Klinika Idegsebészeti Osztálya

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Clinical Neuroscience

[Debate over nervism]

ZÁDOR Imre

[The Academy of Sciences of the USSR and the Academy of Medical Sciences held a joint meeting in June this year to hold a public debate on nervism. A paper by Comrade Stalin entitled "On Marxism in Linguistics" was published in the Pravda a few days before the meeting.]

Clinical Neuroscience

[Central and paracentral homonymous scotomas in circumscribed lesions of the occipital lobe]

MAJERSZKY Klára

[Description of four cases of homonymous hemianopsia scotoma of different and unusual origin (three paracentral and one central). In one case, electrocoagulation of the occipital polus caused a central hemianopsia scotoma without macular sparing, supporting the principle of unilateral cortical representation of the macula.]

Clinical Neuroscience

[Vegetative nervous system association with the combined use of Cardiazol and Evipan]

ZÁDOR Imre, FRIGYESI György

[According to Pavlov and his students, inhibition and stimulation interact dynamically within the nervous system. The authors tried to enhance the two processes simultaneously with Cardiazol and Evipan, respectively, and investigated the equilibrium between the two effects. Evipan also prevents Cardiazole from causing seizures, elevating blood pressure and heart rate, and inducing psychic excitement. The experiments suggest that both Cradiazole and Evipan act mainly on the cerebral cortex and that their neutralising role would take place there. From the experiments and from the parallel therapeutic experience, it appears that Evipan can also be used as an antiepileptic, especially in status epilepticus.]

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Clinical Neuroscience

[Comparative analysis of the full and shortened versions of the Oldenburg Burnout Inventory]

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[Background – The two free-to-use versions of the Oldenburg Burnout Inventory (OLBI) have been increasingly utilised to assess the prevalence of burnout among human service workers. The OLBI has been developed to overcome some of the psychometric and conceptual limitations of the Maslach Burnout Inventory, the gold standard of burnout measures. There is a lack of data on the structural validity of the Mini Oldenburg Burnout Inventory and the Oldenburg Burnout Inventory in Hungary. Purpose – To assess the structural validity of the Hungarian versions of the Oldenburg Burnout Inventory and the Mini-Oldenburg Burnout Inventory. Methods – We enrolled 564 participants (196 healthcare workers, 104 nurses and 264 clinicians) in three cross-sectional surveys. In our analysis we assessed the construct validity of the instruments using confirmatory factor analysis and internal consistency using coefficient Cronbach’s α. Results – We confirmed the two-dimensional structure (exhaustion and disengagement) of the Mini-Oldenburg Inventory and a shortened version of the Oldenburg Burnout Inventory Internal consistency coefficient confirmed the reliability of the instruments. The burnout appeared more than a 50 percent of the participants in every subsample. The prevalence of exhaustion was above 54.5% in each of the subsamples and the proportion of disengaged clinicians was particularly high (92%). Conclusions – Our findings provide support for the construct validity and reliability of the Hungarian versions of the Mini-Oldenburg Burnout Inventory and a shortened version of the Oldenburg Burnout Inventory in the assessment of burnout among clinicians and nurses in Hungary.]

Clinical Neuroscience

Risk factors related to intracranial infections after transsphenoidal pituitary adenomectomy under endoscope

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Background – Up to now, the risk factors related to intracranial infections after transsphenoidal pituitary adenomectomy remain controversial. Purpose – To analyze the risk factors related to intracranial infections after transsphenoidal pituitary adenomectomy under an endoscope, and to provide evidence for preventing and controlling the occurrence and development of infections. A total of 370 patients receiving endoscopic transsphenoidal pituitary adenomectomy in our hospital from January 2014 to October 2017 were selected. The risk factors related to postoperative intracranial infections were analyzed. The hospitalization lengths and expenditures of patients with and without intracranial infections were compared. Of the 370 patients, 18 underwent postoperative intracranial infections, with the infection rate of 4.86%. Intraoperative blood loss >120 mL, cerebrospinal leakage, diabetes, preoperative use of hormones, macroadenoma as well as surgical time >4 h all significantly increased the infection rate (P<0.05). Preoperative use of antibacterial agents prevented intracranial infection. Compared with patients without intracranial infections, the infected ones had significantly prolonged hospitalization length and increased expenditure (P<0.05). Discussion – It is of great clinical significance to analyze the risk factors related to intracranial infection after endoscopic transsphenoidal pituitary adenomectomy, aiming to prevent and to control the onset and progression of infection. Intracranial infections after endoscopic transsphenoidal pituitary adenomectomy were affected by many risk factors, also influencing the prognosis of patients and the economic burden.