Clinical Neuroscience

[Quality of life in children and adolescents with epilepsy]

NIKL János1

JULY 20, 1996

Clinical Neuroscience - 1996;49(07-08)

[The quality of life issues in 95 patients with mild or moderate epilepsy between the ages 7-18 were evalvated by a questionnaire. The author analysed the emotional, interpersonal, vocational adjustments; adjustments to seizures; family backgrounds, financial status, medical management and overall psychosocial functioning. The data indicated a relatively high incidence of psychosocial problems among epileptics. The reason for these changes are multifactorial they include biological, psychic and social variables. However the rate of dysfunctions in childhood seems to be lower than expected. The higher rate observed in the case of adults suggest that psychosocial disturbances become more violent later on, they may culminate in a mid-life crisis. In order to prevent such a situation, some tasks regarding the biological conditions, a teaching-programme on epilepsy, choice of career, getting a driving licence and an alternative model for the medical management are proposed to be carried out.]


  1. Zala Megyei Kórház, Neurológiai Osztály, Zalaegerszeg



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[Changes in prolactin and cortisol levels after partial epileptic seizures]


[Within the framework of presurgical evaluation 14 therapy resistant partial epileptic patients were studied. The prolactin and cortisol serum levels were measured in 15 partial seizures 15, 30 and 60 minutes after the beginning of seizures. Based on the localization of the siezure start on the EEG, ictal, interictal SPECT, MRI and neuropsychological findings the patients were devided into two groups: temporal lobe epilepsy (TLE) and extratemporal epilepsy (ETE). The hormone level measurement was carried out during video-EEG monitoring. In the 11 TLE patients prolactin level increase was found in all cases after the seizures either in the 15th or in the 30th minute samples. In the 4 ETE patients similar increase was found only in 1 patient. Cortisol level increase was found in 10 of the 11 TLE patients and in 2 of the 4 ETE patients. Our findings support the view according which prolactin and cortisol increases occur after seizures involving the temporo-limbic structures. Hormone level peaks are not obligatory consequences of partial epileptic seizures therefore there is no real point in differentiating between epileptic and pseudoepileptic seizures. ]

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[Background and purpose - Data on the disease burden of Duchenne Muscular Dystrophy are scarce in Hungary. The aim of this study was to assess patients’ and their caregivers’ health related quality of life and healthcare utilisations. Methods - A cross sectional survey was performed as part of the European BURQOL-RD project. The EQ-5D-5L and Barthel Index questionnaires were applied, health care utilisations and patients’ informal carers were surveyed. Results - One symptomatic female carer, 50 children (boys 94%) and six adult patients (five males) participated in the study, the latter two subgroups were included in the analysis. The average age was 9.7 (SD=4.6) and 24.3 (SD=9.8) years, respectively. Median age at time of diagnosis was three years. The average EQ-5D score among children and adults was 0.198 (SD=0.417) and 0.244 (SD=0.322), respectively, the Barthel Index was 57.6 (SD=29.9) and 53.0 (SD=36.5). Score of satisfaction with healthcare (10-point Likert-scale) was mean 5.3 (SD=2.1) and 5.3 (SD=2.9). 15 children were hospitalised in the past 12 months for mean 12.9 (SD=24.5) days. Two patients received help from professional carer. 25 children (mean age 11.1, SD=4.4 years) were helped/supervisied by principal informal carer (parent) for mean 90.1 (SD=44.4) hours/week and further family members helped in 21 cases. Correlation between EQ-5D and Barthel Index was strong and significant (0.731; p<0.01) as well as with informal care time (-0.770; p<0.01), but correlation with satisfaction with health care was not significant (EQ-5D: 0.241; Barthel Index: 0.219; informal care: -0.142). Conclusion - Duchenne muscular dystrophy leads to a significant deterioration in the quality of life of patients. Parents play outstanding role in the care of affected children. This study is the first in the Central and Eastern European region that provides quality of life data in this rare disease for further health economic studies.]

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