Clinical Neuroscience

[Pathophysiology of subacute encephalopathies]

TARISKA István1

OCTOBER 01, 1969

Clinical Neuroscience - 1969;22(10)

[The author concludes, on the basis of neuropathological studies, that the criteria for the classification of Creutzfeldt-Jakob disease and related conditions into groups, neither by the quality of histological lesions nor by their topographical distribution, are sufficiently certain to be implemented without objection. In the vast majority of cases, histopathological signs of subacute spongiform encephalopathy are present; the classic Creutzfedt-Jakob syndrome is rare. The nature of the lesions suggests exogenous pathogenesis, primarily through damage to astrocytes. He attributes histological signs suggestive of a pathogenetic responsibility of the circulatory, oxidative or vasodilator (area maxima near poles or at vascular boundaries) to general craniocerebral dynamics known in diffuse brain diseases and not primarily to pathological factors. It argues that Creutzfeldt-Jakob disease is a disorder distinct from Pick's and Alzheimer's disease. Nevertheless, there are difficulties in differentiating (circumscribed brain atrophy, argyrophilic lesions). In one case of amyotrophic dementia, hyaline inclusions were observed in motor neurons of the spinal cord.]

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  1. Országos Ideg- és Elmegyógyintézet Neuropathologiai Laboratórium és az Orvostovábbképző Intézet Ideggyógyászati Tanszék

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