Clinical Neuroscience

[Pathologically proven cases of inferior posterior cerebellar artery occlusion. The two types of bulbar s lateralis syndrome]

DÉNES László1, PERNECZKY Mária1

MAY 01, 1963

Clinical Neuroscience - 1963;16(05)

[In our two clinically classic cases of Wallenberg's syndrome, we established a diagnosis of infernal post-thrombotic occlusion of the cerebellum. In both cases, the pathological findings confirmed that the lateral syndrome observed was caused by infernal post-thrombotic occlusion of the cerebellar. The literature data and our own older observations suggest that there is an upper lateral oblongata syndrome (occlusion of the a. fossae bulbi) and a lower lateral oblongata syndrome due to occlusion of the inf. post. a. cerebelli. In the latter syndrome there is vocal cord paresis, and accordingly in our cases we have demonstrated severe laesions of the middle and lower part of the nucl. ambiguus. ]

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  1. Bács-Kiskun Megyei Tanács Kórháza Ideggyógyászata és Kórbonctana

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Clinical Neuroscience

[Analysis of 19 cases of syncope]

DÚS Vince

[In summary, 1. with the exception of the 3 cases with epilepsy, resting electrical activity, even if abnormal, does not appear to be specific and cannot be associated with syncope; 2. syncope, although in the majority of cases an independent pathology, may be associated with epilepsy (cases 1 and 2) and even, we hypothesize, may be a trigger of epilepsy (case 3); In case 3, the electrographic findings support the conclusion that the cause of the malocclusions is, as Gastaut et al. have already shown, cerebral anoxia caused by asystole or bradycardia; 4 Our case 4 suggests that the pathomechanism of cough syncope may involve a vagocardial reflex mechanism; 5. syncope can be induced by Megimide in addition to Cardiazolone. To our present knowledge, there is no link between epilepsy and the pathomechanism of syncope. However, syncope provoked by Cardiazole and Megimide deserves further study in the direction of the nature of the central mechanism that leads to the suspension of cardiac function.]

Clinical Neuroscience

[Topical use of streptomycin in the treatment of pain syndromes]

HALÁSZ Imre, ZAPPE Lajos

[Authors have reported local pain reduction with streptomycin in the local treatment of laryngeal TB. On the basis of this observation, they have regularly treated post-tooth extraction and neuralgia pain with str. The clinical data of 24 patients with trigeminal neuralgia and 1 patient with glossopharyngeal neuralgia are described in detail. Their observations indicate that the above effect of str. is produced by functional blockade of the nerve pathways that conduct pain. ]

Clinical Neuroscience

[Cerebral ventricular rupture in hydrocephalus occlusus]

SCHÉDA Vilmos, CSANÁDI László

[The authors describe their 25-year case of hydrocephalus. The aquaeductus sylvii was occluded by a 1 mm thick glial membrane, causing occlusive hydrocephalus. During the development of hydrocephalus, spontaneous improvement occurred because the ventricular wall in the left frontal convexity was ruptured and CSF was allowed to be absorbed into the subarachnoid space. In their case, he was familiar with the forms of aquaeductal obstruction, the atrophy of brain matter in hydrocephalus and the outcome, including the possibility of spontaneous recovery.]

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Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study

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We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

Clinical Neuroscience

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Clinical Neuroscience

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Clinical Neuroscience

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Clinical Neuroscience

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