Clinical Neuroscience

[Paraneoplastic chronic demyelinating neuropathy and lambert-eaton myasthenic syndrome associated with multiple anti-neural antibodies and small-cell lung cancer]

RÓZSA Csilla1, VINCENT Angela2, ARÁNYI Zsuzsanna3, KOVÁCS G. Gábor4, KOMOLY Sámuel5, ILLÉS Zsolt5

SEPTEMBER 30, 2008

Clinical Neuroscience - 2008;61(09-10)

[Lambert-Eaton myasthenic syndrome (LEMS) developed in a patient with presumed chronic inflammatory demyelinating polyneuropathy (CIDP) and negative chest CT. Since antibodies against both Hu and voltage-gated calcium channel (VGCC) were detected, repeated chest CT was performed, which eventually showed a pulmonary mass lesion. Biopsy revealed small cell lung cancer (SCLC) indicating the importance of repeated chest CT in LEMS even when an existing autoimmune-like disease and negative CT may suggest an autoimmune origin. This is the first report of paraneoplastic CIDP and LEMS associated with anti-Hu, anti-VGCC and SCLC.]

AFFILIATIONS

  1. Jahn Ferenc Teaching Hospital, Budapest
  2. Institute of Molecular Medicine, John Radcliffe Hospital, Oxford
  3. Department of Neurology, Semmelweis University, Budapest
  4. Department of Neuropathology, National Institute of Neurology and Psychiatry, Budapest
  5. Department of Neurology, University of Pécs, Pécs, Hungary

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