Clinical Neuroscience

[Our experience with Parkazine and its combination with other antiparkinsonian medicines]

DOBI Sándor1

AUGUST 01, 1963

Clinical Neuroscience - 1963;16(08)

[Following Klimes' positive experience with outpatients, we have also had positive experience with Parkazine in hospital, which is mostly more severe. We have experienced a pronounced antitremor effect and we have experienced what was definitely an advantage over other previous drugs, that it also has a significant antitremor effect. This anti-tremor effect, which is all the shorter the patient's anamnesis, is the main advantage of Parkazine and justifies its use in all cases of Parkinson's syndrome. In addition to its beneficial effects on tremor and rigor, it also significantly improves akinesia through rigor reduction, without affecting primary motor impulsion. The latter should be classified as psychic symptoms, which are not affected by parkazine. Nevertheless, it does have a significant secondary psychic effect, which can be attributed to an improvement in the ability of helpless tremor patients to move and a reduction in tremor, by which the emotional afficiability of patients is also reduced. To influence the autonomic phenomena, which are a sub-symptom of Parkinson's syndrome and which greatly impair social integration, the drug can be preferably combined with belladonna derivatives, in our experience most notably Bellafit. This implies, accepting the different localisation mechanisms of the main components of PD, that Parkazine targets the areas involved in the generation of PD tremor and rigorous tonicity. ]

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  1. Gyulai Megyei Kórház Ideg-Elmeosztálya

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[The authors report on cholinesterase enzyme activity assays of operated subdural and intracerebral haematoma specimens. By determining the cholinesterase and acetylcholinesterase activity of the fluid obtained at surgery, they attempted to draw parallels between enzyme activity and the time of haematoma persistence. The results showed that the fluid content of the capsular haematoma is not stable from the time of formation. The variation in the activity of the two enzymes studied suggests the possibility that the fluid content is continuously replenished, presumably by transudation.]

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[Analysis of symptomatic epipharyngeal tumour cases with trigeminal neuralgia]

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[The authors report the results of surgical treatment of 28 spontaneous intracerebral haematomas. In 12 cases, the cause of the haemorrhage was hypertonic arteriosclerosis based on clinical investigations; in 2 juvenile patients the haemorrhage was due to a microangioma undetectable by angiography, while in the other cases the aetiology was unknown. The cases were classified into 3 groups according to onset and course : 1. pseudotumoral or chronic form, 2. apoplectiform onset and 3. subarachnoid haemorrhage. The distribution of haematomas according to localisation was as follows: frontal 5, temporal 8, capsular 5, trigonal 9, cerebellar 1. Of the 28 patients, 5 died (18% surgical mortality). Of the 10 patients operated on within two weeks, 4 died, and of the 18 operated on later, 1 died. Despite the strikingly better results of late surgery, categorical avoidance of early intervention is not possible, but requires individual assessment of the surgical indicatio, especially in acute fasciitis. ]

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[By means of modern technology and organization of work, the effect of stress on the nervous system caused by factors outside the objective nature of the work process can be substantially reduced in the case of production on the production line. The success of the measures aimed at reducing the strain on the nervous system of people working on the production line can only be increased if the stress situation resulting from the nature of the work process is changed. Since the repetitive and uniform manipulations during the bound work process primarily require an adaptation of the individual tempo and rhythm within narrow limits, the nervous system load on the working person is reflected in the mental performance of the adaptation at the given moment of time. The investigations concerning time perception have shown the necessity of improving the working conditions in two areas with regard to the further reduction of the nervous system load: 1. in order to further limit monotony, the linking of the tasks on the production line must be regulated in a new way, 2. in order to facilitate time adaptation, more micro-breaks must be inserted between the individual tasks on the production line than before.]

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