Clinical Neuroscience

[Hypophosphataemia, myopathy, diabetes mellitus: case history]

MERKLI Hajnalka1, GÁTI István1, WITTMANN István2, PFUND Zoltán1, CZOPF József1

JULY 20, 1997

Clinical Neuroscience - 1997;50(07-08)

[The case history of a 47-year-old woman is reported. From her puberty, diffuse muscle pains and cramps appeared in her musclers after physical activities, with no complaints during rest. She was submitted to scalenotomy because of pains in her right arm, without any influence of her condition. Myopathy was detected by electromyography and muscle biopsy. Later, hypophosphataemia and diabetes mellitus were found by repeated laboratory investigations. Detailed internal medical, endocrinological and biochemical investigations were not able to demonstrate any other abnormalities. The ultrastructure of the muscle exhibited vacuolar degeneration. Phosphate supplementation resulted in clinical improvement and normalization of the laboratory findings. Our results demonstrate the pathogenetic background of muscle damage and correlations between the phosphate metabolism, diabetes mellitus, myopathy, and tubulopathy.]

AFFILIATIONS

  1. Pécsi Orvostudományi Egyetem, Neurológiai Klinika
  2. II. Belgyógyászati Klinika, Pécs

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