Clinical Neuroscience

[How our view of epileptogenesis and mechanism of epilepsy changes? The system epilepsies’ concept]

HALÁSZ Péter1, SZÛCS Anna2

MARCH 31, 2022

Clinical Neuroscience - 2022;75(03-04)

DOI: https://doi.org/10.18071/isz.75.0079

Review

[To examine the ways of epileptogenesis closely linked to the system epilepsies’ concept. We follow the ways of epileptic transformation in the declarative memory-system, in the sleep/arousal twin-systems, in the perisylvian neuronal network and in postinjury epilepsy, which we consider a general model of the epileptic transformation. In the presented systems, epileptogenesis shares a similar mechanism in the form of augmentation and derailment of plasticity and sleep-related synaptic homeo­stasis. This highlights the central role of NREM sleep in those epilepsies. We try to characterize the concept of system epilepsies and suggest a shared mechanism of epileptogenesis. ]

AFFILIATIONS

  1. Országos Mentális Ideggyógyászati és Idegsebészeti Intézet, Budapest
  2. Semmelweis Egyetem, Magatartástudományi Intézet, Budapest

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