Clinical Neuroscience

[Determination of serum C-reactive protein in the illnesses of central nervous system]

PINTÉR Erzsébet1, KÁLI Gábor2, VUKMIROVITS György3, NIKOLOVA Radka3, YOUSEF M. Gassar2, GYARMATI Éva4

NOVEMBER 20, 1994

Clinical Neuroscience - 1994;47(11-12)

[Serum quantitative C-reactive protein concentrations were measured in 186 patients admitted with suspected neuroinfection or symptoms of other diseases in the central nervous system. The diagnoses were purulent meningitis (102), abscessus cerebri (5), meningitis basilaris (2), meningitis cryptococcica (1), sepsis (11), encephalitis (22), encephalopathia (5), autoimmune central nervous illness/disease/disorder (22), non-inflammatory central nervous disease/ disorder (12) and tumour cerebri (4). The highest values of C-reactive protein were measured in patients suffering from abscessus cerebri (250.8 +/ 64.2 mg/l), sepsis (221 +/- 16.4 mg/l) and purulent meningitis (153.0 +/- 94.59 mg/l). Serum C-reactive protein concentrations were moderately increased in viral infections (36.8 +/- 36 mg/l). The C-reactive protein level in the normal range in patients suffering from non-inflammatory and autoimmune central nervous illnesses/diseases/ disorders (4.0 +/- 1.5 mg/l or 10.0 +/- 18.5 mg/l). During our examinations the C-reactive protein levels showed both local and septicaemic reactions. C-reactive protein is considered as a valuable laboratory parameter both in diagnosings central nervous system diseases with suspected bacterial infection and in monitoring therapeutic efficiency.]

AFFILIATIONS

  1. Fővárosi Szent László Kórház, Municipal St Ladislas Hospital
  2. Neuroinfektológiai Osztály, Department of Neuroinfectology
  3. Központi Intenzív Osztály, Department of Intensive Care Unit
  4. IV. Gyermekosztály, Budapest. IV. Children's Department

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