Clinical Neuroscience

[Data for the pathogenesis of morphinismus]

GARTNER Pál1, KELEMEN Endre1

JULY 29, 1952

Clinical Neuroscience - 1952;5(02)

[Since December 1950, authors have performed morphine withdrawal treatment on 32 morphine users referred from the KEKSZ. Their procedure is as follows: morphine is withdrawn immediately. On the first day of withdrawal, the patient receives 0.1-0.1 ccm of 2% morphine intracutaneously into the flexor aspect of both forearms, for a total of 4 mg. The same is given for the next 3 days. The fifth day is a break. On the sixth and seventh days he receives the same again. In addition: on days 1-3-6, another 3-5-10 ccm of foreign group blood is given intravenously. If there is an obstacle to hetero-blood injection, 10 ccm Resactor is given intramuscularly instead. This procedure is used to minimise withdrawal symptoms, and mood correctors are rarely needed. Patients usually leave on day 10 with no symptoms or complaints. The pathogenesis of morphinism is thought to be essentially immunobiological. They consider their new withdrawal treatment to be intracutaneous desensitisation and attribute the success of the treatment to the reduction in tolerance induced by the binding of morphine antibodies. Hetero-blood or Resactor injections mobilise antibodies through their effect on the RES system, which enhances the efficacy of the treatment. Treatment does not resolve the issue of relapse. ]

AFFILIATIONS

  1. Fővárosi Korányi Frigyes és Sándor Kórház Elme-Idegosztálya

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