Clinical Neuroscience

Biologie moléculaire du neuroblastome

JEAN Bénard1

NOVEMBER 20, 1997

Clinical Neuroscience - 1997;50(11-12)

Plusieurs anomalies génétiques ont été découvertes dans le neuroblastome: une délètion du bras court du chromosome 1, une amplification de l'oncogène N- myc et une absence d'expression du gène CD44. Ces altérations ont une valeur pronostique dans les formes localisées de la maladie et permettent d'améliorer le traitment: intensifier la chimiotpérapie pour les formes agressives, diminuer au contraire ce traitement pour les formes non agressives.

AFFILIATIONS

  1. Unité des Marqueurs Génétiques des Cancers, Institut Gustave Roussy, Villejuif France

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