Clinical Neuroscience

[Before setout...]

Z. I.

MARCH 23, 1950

Clinical Neuroscience - 1950;3(01)

[The first psychiatric and neurological journal in Hungary is now launched. The support of the Academy of Sciences and the Medical-Health Trade Union made it possible to make up for the omission made by the pseudo-scientific cultural policy of the reactionary period. It has already happened in the past that Hungarian medicine started to flourish. Developments in the fields of neurophysiology, neurology and psychiatry began in the second half of the last century, during which Hungarian researchers were connected to the leading medical discoveries of the time in the world.]

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Clinical Neuroscience

[The value of newer liver function tests in cases of alcoholism chronicus ]

CSORBA Antal , LÁNG Sándor

[In mild cases of chronic alcoholism with newer liver function tests for liver damage can be detected in approx. 50%, in more severe clinical cases in 90%. In mild cases there is no globulin proliferation, in more severe cases it is most often.]

Clinical Neuroscience

[Hydrocephalus-induced ventricular diverticulum in the cistern ambiens]

KAJTOR Ferenc, HABERLAND Katalin

[The authors report 5 cases of cerebral ventricular dysfunction developed as a result of occlusive hydrocephalus, 3 of which with one or both lateral chambers and 2 traveling with the III. chamber. Clinical, pneumographic, macroscopic, and microscopic autopsy findings and the likely mechanism of diverticulum formation are described. It is found that the detection of a significant size diverticulum by pneumography is a well-marketed diagnostic and prognostic physiologically very favorable, although not easy, surgical solution.]

Clinical Neuroscience

[Influence of blood glucose balance with ergotamine content (Gynergen)]

ZÁDOR Imre, KOVÁCS M. Erzsébet

[A review of the literature in recent years found no report on the effects of ergotamine (Gynergen) on blood glucose, but 20 years ago, Hetényi reported essentially similar results based on studies in two patients. He stressed that in all likelihood, Ergotamine does not delay intestinal absorption.]

Clinical Neuroscience

[New aspects of Friedreich's disease]

LEHOCZKY Tibor, NÉMETH Jenő

[4 clinical observations of Friedreich's disease. 3 male, 1 female: three "pure" forms, one with amyotrophic lat. sclerosis. Heredofamilial trait in 3 cases: two patients had pes excavatus in the brother, the second patient had Dupuytren's contacture of the little finger. The 3rd case had a marked myocardial laesio; this was absent in the others. This therefore does not support the hypothesis that myocarditis and neurological lesions are caused by a common toxic agent.]

Clinical Neuroscience

[Familiaris myasthenia]

CSORBA Antal

[The significantly higher prevalence of the pathology among women, menstruation, natural or artificial menopause, the undoubted influence of pregnancy, persistent thymus, etc., demonstrate the aetiological importance of endocrine factors. It is probable that the so-called constitutional factor is nothing more than an as yet unknown disorder of the endocrine system and that it forms the basis of the chemical mediator disorder.]

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[Current issues in the peripartum management of diabetic women from the perspective of an internist-diabetologist]

KERÉNYI Zsuzsanna

[In pregnancy complicated with diabetes, treatment of hyperglycaemia is of fundamental importance during delivery in order to improve the outcome parameters of both the mother and the neonate. This is particularly important in the case of mothers with type 1 diabetes and of all mothers who require insulin treatment during their pregnancy. The use of antenatal steroids for women at risk of pre-term birth further complicates the treatment of hyperglycaemia in the period immediately before delivery and requires the appropriate change of insulin therapy. The requirement of nil per os in the delivery period necessitates proper fluid, glucose and insulin treatment in the pre-delivery hours. After surgical delivery the patients may also need infusion treatment until the first meal. As there is no unified guideline for the peripartum management of diabetes, the author re­views the international literature on the internal medicine issues concerning the peripartum treatment of pregnant women with diabetes. This study reviews the characteristics of insulin treatment of women with various types of diabetes before, du­ring and di­rect­ly after delivery. It presents a dosing schedule for women who needed an antenatal steroid treatment in the period before delivery due to premature birth for the purpose of lung maturation. The study also addresses the application and programming of pe­ripartum blood glucose tests, continuous interstitial glucose monitoring (CGM) and insulin pump treatment (CSII).]

Clinical Neuroscience

Acute transverse myelitis after inactivated COVID-19 vaccine

ERDEM Şimşek Nazan, DEMIRCI Seden, ÖZEL Tuğba , MAMADOVA Khalida, KARAALI Kamil , ÇELIK Tuğba Havva , USLU Ilgen Ferda, ÖZKAYNAK Sibel Sehür

Vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been rapidly developed to prevent coronavirus disease 2019 (COVID-19) pandemic. There is increasing safety concerns regarding COVID-19 vaccines. We report a 78-year old woman who was presented with tetraparesis, paresthesias of bilateral upper extremities, and urinary retention of one-day duration. Three weeks before these symptoms, she was vaccinated with CoronaVAC vaccine (Sinovac Life Sciences, China). Spine magnetic resonance imaging showed longitudinally extensive transverse myelitis (TM) from the C1 to the T3 spinal cord segment. An extensive diagnostic workup was performed to exclude other possible causes of TM. We suggest that longitudinally extensive TM may be associated with COVID-19 vaccination in this case. To the best of our knowledge, this is the first report of longitudinally extensive TM developing after CoronaVac vaccination. Clinicians should be aware of neurological symptoms after vaccination of COVID-19.

Clinical Neuroscience

[Sleep habits among preschool- and schoolchildren]

FUSZ Katalin, RITECZ Bernadett, BALOGH Brigitta, TAKÁCS Krisztina, SOMLAI Eszter, RAPOSA L. Bence, OLÁH András

[Objective - Our aim is to evaluate sleep habits, sleep quality and influencing factors among preschool- and schoolchildren. Method - Two questionnaires were recorded. Questionnaire 1 dealt with sleeping habits, breastfeeding and health behavior of preschool children and infant, and it contained the abbreviated version of the Children’s Sleep Habits Questionnaire. Questionnaire 2 dealt with health behavior and the application of sleep hygiene rules, as well as it contained the Athens Insomnia Scale. Subjects - We assessed a total of 1063 questionnaires: 516 kindergarten children participated in our online survey across the country; 547 primary and secondary school students participated in the 2nd questionnaire survey in Szolnok. Results - Parents’ observation shows that the average nighttime sleeping time of kindergarten children is 10 hours 20 minutes on weekdays and 10 hours 36 minutes on weekends. The most popular sleeping habits in kindergarten age: teal reading (65.1%) and co-sleeping (42.8%). Parents of infants used breastfeeding (50.4%) and rocking (43.2%) most frequently before sleep. Co-sleeping has a positive influence on the length of lactation. Among the preschool sleeping habits we have proved a number of positive effects of teal reading, while watching television have negative effects. The sleep quality of school-age children according to the Athens Insomnia Scale is 6.11 points (SD: 4.11), 19% of the children are insomniac. Their sleep time is 7 hours 31 minutes on weekdays and 9 hours 30 minutes on weekends. The usage of good health behavior and sleep hygiene rules positively influence sleep quality and sleep duration. Conclusions - With our results, we would like to draw the attention of children and parents to the importance of sleeping and using sleep hygiene rules.]

Clinical Neuroscience

How to manage MuSK antibody-positive myasthenic crisis during pregnancy?

ÇETİNER Mustafa , AKDAĞ Gönül , AKKOYUN ARIKAN Fatma, CANBAZ KABAY Sibel

Myasthenia gravis (MG) is an autoimmune disease that is characterised by the formation of antibodies against acetylcholine receptors in the postsynaptic membrane of the neuromuscular junction. The course of the disease cannot be predicted during pregnancy. A subtype of MG with positive muscle-specific receptor tyrosine kinase (anti-MuSK) antibodies exhibits more localised clinical characteristics and a poor response to treatment compared with the disease subtype that involves positivity for acetylcholine receptor antibodies. Myasthenic crisis is more frequently observed in anti-MuSK-positive myasthenia patients. Anti-MuSK-positive myasthenic crisis management is very difficult and a risky situation during pregnancy. The reported case was 30 years old, female, 9 weeks pregnant and musk antibody positive. She stopped her treatment without asking her doctor because she was planning pregnancy in the 6-month period before her hospitalization. She was intubated for a long time in the intensive care unit due to myasthenic crisis and was very resistant to treatment. During this period, her pregnancy was terminated due to fetal anomaly. Plasmapheresis, IVIg and immunosuppressive treatments were applied. Our patient was discharged after a period of about 10 weeks. We share our treatment management.